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Triptodur Generic Name & Formulations
Legal Class
Rx
General Description
Triptorelin pamoate 22.5mg; lyophilized microgranules for ext-rel IM inj after reconstitution; contains mannitol.
Pharmacological Class
GnRH agonist.
How Supplied
Single-use kit—1
Manufacturer
Generic Availability
NO
Triptodur Indications
Indications
Central precocious puberty.
Triptodur Dosage and Administration
Adult
Not applicable.
Children
<2yrs: not established. Give as IM inj in buttock or thigh. ≥2yrs: 22.5mg once every 24 weeks. Discontinue at appropriate time point for onset of puberty. Consider switching to alternative GnRH agonist if Triptodur dose is inadequate.
Triptodur Contraindications
Contraindications
Pregnancy.
Triptodur Boxed Warnings
Not Applicable
Triptodur Warnings/Precautions
Warnings/Precautions
Use aseptic technique. Must be administered by a healthcare provider. Initial transient rise in gonadotropins and sex steroids may result in increased signs/symptoms of puberty. Monitor LH and sex steroid levels at 1–2 months after treatment initiation, during, and with each subsequent dose. Measure height every 3–6 months and bone age periodically. Monitor for pseudotumor cerebri or psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Renal or hepatic impairment. Discontinue if overdosage occurs. Nursing mothers.
Triptodur Pharmacokinetics
Elimination
Renal, hepatic.
Triptodur Interactions
Interactions
Concomitant hyperprolactinemic drugs: not recommended. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs). May interfere with pituitary gonadotropic and gonadal function tests.
Triptodur Adverse Reactions
Adverse Reactions
Inj site reactions, menstrual bleeding, hot flush, headache, cough, infections (eg, bronchitis, gastroenteritis, influenza, nasopharyngitis, otitis externa, pharyngitis, sinusitis, upper respiratory tract infection).
Triptodur Clinical Trials
See Literature
Triptodur Note
Not Applicable
Triptodur Patient Counseling
See Literature
