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Supprelin La Generic Name & Formulations
Legal Class
Rx
General Description
Histrelin acetate 50mg; SC implant.
Pharmacological Class
GnRH agonist.
How Supplied
Kit—1 (w. implant and insertion tool)
Manufacturer
Generic Availability
NO
Supprelin La Indications
Indications
Central precocious puberty.
Supprelin La Dosage and Administration
Adult
Not applicable.
Children
<2yrs: not recommended. ≥2yrs: Insert 1 implant SC in the inner aspect of the upper arm. Remove after 12 months; may replace. Consider discontinuing at appropriate time point for onset of puberty.
Supprelin La Contraindications
Contraindications
Pregnancy.
Supprelin La Boxed Warnings
Not Applicable
Supprelin La Warnings/Precautions
Warnings/Precautions
Use aseptic technique. Initial transient rise in gonadotropins and sex steroids may result in increased signs/symptoms of puberty. Monitor for pseudotumor cerebri or psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Monitor LH, FSH, and estradiol or testosterone at 1 month post implantation, then every 6 months thereafter. Assess height and bone age every 6–12 months. Nursing mothers.
Supprelin La Pharmacokinetics
See Literature
Supprelin La Interactions
Interactions
May interfere with pituitary gonadotropic and gonadal function tests. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs).
Supprelin La Adverse Reactions
Adverse Reactions
Implant site reactions (eg, discomfort, bruising, pain, soreness, erythema, swelling).
Supprelin La Clinical Trials
See Literature
Supprelin La Note
Not Applicable
Supprelin La Patient Counseling
See Literature
