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Prednisone Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Prednisone 5mg; per 5mL; contains alcohol 5%.
Pharmacological Class
Glucocorticoid.
See Also
How Supplied
Soln—120mL, 500mL; Intensol—30mL (w. dropper)
Manufacturer
Prednisone Oral Solution Indications
Indications
Corticosteroid-responsive disorders.
Prednisone Oral Solution Dosage and Administration
Adults and Children
See literature. Initially 5mg–60mg daily. Intensol: mix with liquid or semi-solid food.
Prednisone Oral Solution Contraindications
Contraindications
Systemic fungal infections. Live vaccines.
Prednisone Oral Solution Boxed Warnings
Not Applicable
Prednisone Oral Solution Warnings/Precautions
Warnings/Precautions
Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers.
Prednisone Oral Solution Pharmacokinetics
See Literature
Prednisone Oral Solution Interactions
Interactions
Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants.
Prednisone Oral Solution Adverse Reactions
Adverse Reactions
HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.
Prednisone Oral Solution Clinical Trials
See Literature
Prednisone Oral Solution Note
Not Applicable
Prednisone Oral Solution Patient Counseling
See Literature
