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Prednisone Intensol Generic Name & Formulations
Legal Class
Rx
General Description
Prednisone 5mg; per 1mL; concentrated soln; contains alcohol 30%.
Pharmacological Class
Glucocorticoid.
See Also
How Supplied
Soln—120mL, 500mL; Intensol—30mL (w. dropper)
Manufacturer
Prednisone Intensol Indications
Indications
Corticosteroid-responsive disorders.
Prednisone Intensol Dosage and Administration
Adults and Children
See literature. Initially 5mg–60mg daily. Intensol: mix with liquid or semi-solid food.
Prednisone Intensol Contraindications
Contraindications
Systemic fungal infections. Live vaccines.
Prednisone Intensol Boxed Warnings
Not Applicable
Prednisone Intensol Warnings/Precautions
Warnings/Precautions
Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers.
Prednisone Intensol Pharmacokinetics
See Literature
Prednisone Intensol Interactions
Interactions
Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants.
Prednisone Intensol Adverse Reactions
Adverse Reactions
HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.
Prednisone Intensol Clinical Trials
See Literature
Prednisone Intensol Note
Not Applicable
Prednisone Intensol Patient Counseling
See Literature
