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Orapred Generic Name & Formulations
Legal Class
Rx
General Description
Prednisolone (as sodium phosphate) 15mg/5mL; soln; dye-free; grape flavor; contains alcohol.
Pharmacological Class
Glucocorticoid.
See Also
How Supplied
Soln—237mL; Tabs—48
Manufacturer
Generic Availability
YES
Orapred Indications
Indications
Steroid-responsive disorders.
Orapred Dosage and Administration
Adult
See full labeling. Tabs: swallow whole or dissolve on tongue; do not break or use partial tabs. Initially 5–60mg/day.
Children
See full labeling. Tabs: swallow whole or dissolve on tongue; do not break or use partial tabs. Initially 0.14–2mg/kg per day in 3–4 divided doses.
Orapred Contraindications
Contraindications
Systemic mycoses. Live vaccinations. Cerebral malaria.
Orapred Boxed Warnings
Not Applicable
Orapred Warnings/Precautions
Warnings/Precautions
Tuberculosis. Latent infection (esp. amebiasis). Hypo- or hyperthyroidism. Cirrhosis. Ocular herpes simplex, optic neuritis: not recommended. Avoid exposure to chickenpox or measles; consider prophylactic passive immune therapy if exposure occurs. Renal insufficiency. Ulcerative colitis if perforation pending. Diverticulitis. Peptic ulcer. Hypertension. CHF. Osteoporosis. Diabetes. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Alternate, intermittent or single-daily doses at 8AM minimize adrenal suppression. Monitor weight, growth, fluid and electrolyte balance, and intraocular pressure. Emotional instability. Psychotic tendencies. Embryo-fetal toxicity. Pregnancy (esp. 1st trimester): monitor. Nursing mothers: use lowest dose.
Orapred Pharmacokinetics
See Literature
Orapred Interactions
Interactions
Effects may be decreased by hepatic enzyme inducers (eg, barbiturates, hydantoins, rifampin). May be potentiated by ketoconazole estrogens. Acute myopathy with neuromuscular blockers. Avoid aspirin. Cyclosporine: both drugs potentiated and seizures reported. Monitor warfarin, antidiabetic agents. Avoid anticholinesterases. Monitor if given with potassium-depleting agents, digoxin.
Orapred Adverse Reactions
Adverse Reactions
HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.
Orapred Clinical Trials
See Literature
Orapred Note
Not Applicable
Orapred Patient Counseling
See Literature
