Novolin R Generic Name & Formulations
Legal Class
OTC
General Description
Regular insulin (human, rDNA origin) 100 Units/mL; soln for SC or IV inj.
See Also
How Supplied
Vials (10mL)—1; FlexPen (3mL)—1
Manufacturer
Generic Availability
NO
Novolin R Indications
Indications
Diabetes.
Novolin R Dosage and Administration
Adults and Children
Individualize. SC or IV inj. Rotate inj sites. SC: onset ~30mins, peak 1.5–2.5hrs, duration ~8hrs.
Novolin R Contraindications
Contraindications
During episodes of hypoglycemia.
Novolin R Boxed Warnings
Not Applicable
Novolin R Warnings/Precautions
Warnings/Precautions
Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not reuse or share pens, needles, or syringes between patients, even if the needle is changed. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia or hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.
Novolin R Pharmacokinetics
See Literature
Novolin R Interactions
Interactions
Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, salicylates, somatostatin analogs (eg, octreotide), sulfonamide antibiotics. Antagonized by atypical antipsychotics, corticosteroids, isoniazid, niacin, danazol, diuretics, glucagon, phenothiazines, sympathomimetics, somatropin, thyroid hormones, oral contraceptives, estrogens, progestogens, protease inhibitors. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia.
Novolin R Adverse Reactions
Adverse Reactions
Hypoglycemia, allergic reactions, inj site reactions, lipodystrophy, weight gain, hypokalemia, peripheral edema.
Novolin R Clinical Trials
See Literature
Novolin R Note
Not Applicable
Novolin R Patient Counseling
See Literature