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Nateglinide Generic Name & Formulations
Legal Class
Rx
General Description
Nateglinide 60mg, 120mg; tabs.
Pharmacological Class
Glinide.
How Supplied
Contact supplier
Manufacturer
Nateglinide Indications
Indications
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Limitations of Use
Not for treatment of type 1 diabetes or diabetic ketoacidosis.
Nateglinide Dosage and Administration
Adult
Take 1–30mins before meals; skip dose if meal is skipped. 120mg 3 times daily. If near glycemic goal, initially 60mg 3 times daily.
Children
Not established.
Nateglinide Contraindications
Not Applicable
Nateglinide Boxed Warnings
Not Applicable
Nateglinide Warnings/Precautions
Warnings/Precautions
Increased risk of hypoglycemia with changes in physical activity, meal patterns, renal or hepatic impairment: monitor glucose more frequently and may need to adjust dose. Reduced symptomatic awareness of hypoglycemia in longstanding diabetes, diabetic nerve disease, or recurrent hypoglycemia. Moderate-to-severe hepatic impairment. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nateglinide Pharmacokinetics
See Literature
Nateglinide Interactions
Interactions
Increased hypoglycemia with concomitant other antidiabetic agents, NSAIDs, salicylates, MAOIs, non-selective β-blockers, anabolic hormones, guanethidine, and CYP2C9 inhibitors (eg, amiodarone, fluconazole, voriconazole, sulfinpyrazone), alcohol; may need dose reduction and monitor. May be antagonized by thiazides, corticosteroids, thyroid products, sympathomimetics, somatropin, somatostatin analogs (eg, lanreotide, octreotide), and CYP inducers (eg, rifampin, phenytoin, St John's Wort); may need dose increase and monitor. β-blockers, clonidine, guanethidine, reserpine may mask hypoglycemia.
Nateglinide Adverse Reactions
Adverse Reactions
Upper RTI, back pain, flu symptoms, dizziness, arthropathy, diarrhea; hypoglycemia, weight gain.
Nateglinide Clinical Trials
See Literature
Nateglinide Note
Notes
Formerly known under the brand name Starlix.
Nateglinide Patient Counseling
See Literature
