Lyumjev

— THERAPEUTIC CATEGORIES —
  • Diabetes
PAGE CONTENTS
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  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Lyumjev Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Insulin lispro-aabc (rDNA origin) 100 Units/mL, 200 Units/mL; soln for SC inj or continuous SC infusion (insulin pump), or IV infusion after dilution; contains zinc, m-cresol.

    How Supplied

    Lyumjev U-100: multiple-dose vials (10mL)—1; single-patient-use (cartridges [3mL], KwikPen [3mL], Junior KwikPen [3mL], Tempo Pen [3mL])—5; Lyumjev U-200: KwikPen (3mL)—2

    Manufacturer

    Eli Lilly and Company

    Generic Availability

    NO

    Lyumjev Indications

    Indications

    Diabetes mellitus.

    Lyumjev Dosage and Administration

    Adults and Children

    <1yr: not established. ≥1yrs: Individualize. For SC inj (Lyumjev U-100 or U-200): give at the start of a meal or within 20mins after starting a meal; use with intermediate or long-acting insulin. Rotate inj sites (abdomen, thigh, upper arm, buttocks). For continuous SC infusion pump (Lyumjev U-100 only): administer into a region as recommended from pump manufacturer; rotate infusion sites (within the same region); change Lyumjev in the reservoir at least every 9 days, the infusion sets, and insertion site accordingly; see full labeling. For IV inj (Lyumjev U-100 only): dilute to conc. of 1 Unit/mL; give only under medical supervision; closely monitor blood glucose and potassium.

    Lyumjev Contraindications

    Contraindications

    During episodes of hypoglycemia.

    Lyumjev Boxed Warnings

    Not Applicable

    Lyumjev Warnings/Precautions

    Warnings/Precautions

    Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not share pens or cartridges between patients, or needles and syringes when using vials, even if the needle is changed. Visual impairment: will need assistance with prefilled pens. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyper- or hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Insulin pump device malfunction: may cause hyperglycemia, ketoacidosis; have interim SC inj or alternative insulin therapy available. Pregnancy. Nursing mothers.

    Lyumjev Pharmacokinetics

    See Literature

    Lyumjev Interactions

    Interactions

    Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, salicylates, somatostatin analogs (eg, octreotide), sulfonamide antibiotics. Antagonized by atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetics, thyroid hormones. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, or reserpine may blunt hypoglycemia; monitor. Do not mix with any other insulin.

    Lyumjev Adverse Reactions

    Adverse Reactions

    Hypoglycemia, injection/infusion site reactions, allergic reactions, rash, pruritus, lipodystrophy, weight gain, peripheral edema; hypokalemia.

    Lyumjev Clinical Trials

    See Literature

    Lyumjev Note

    Not Applicable

    Lyumjev Patient Counseling

    See Literature

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