Liothyronine Injection Dosage & Rx Info

Liothyronine Injection Generic Name & Formulations

Legal Class

General Description

Liothyronine (as sodium) 10mcg/mL; soln for IV inj.

Pharmacological Class

T₃ (synthetic).

How Supplied

Contact supplier

Manufacturer

X-GEN Pharmaceuticals, Inc

Mechanism of Action

Thyroid hormones enhance oxygen consumption by most tissues of the body and increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. In vitro studies indicate that T3 increases aerobic mitochondrial function, thereby increasing the rates of synthesis and utilization of myocardial high-energy phosphates. This, in turn, stimulates myosin ATPase and reduces tissue lactic acidosis. Thus, thyroid hormones exert a profound influence on virtually every organ system in the body and are of particular importance in the development of the central nervous system.

Liothyronine Injection Indications

Indications

Myxedema coma/precoma.

Liothyronine Injection Dosage and Administration

Adult

Give with glucocorticoids. Allow 4–12 hours between doses. Initially 25–50mcg. Cardiovascular disease: initially 10–20mcg. Usual range: 65–100mcg daily. Change to oral therapy as soon as possible: start tabs at low dose and increase gradually; discontinue IV gradually.

Children

Not established.

Liothyronine Injection Contraindications

Contraindications

Uncorrected adrenocortical insufficiency. Untreated thyrotoxicosis. Artificial rewarming.

Liothyronine Injection Boxed Warnings

Boxed Warning

Not for treatment of obesity for weight loss.

Liothyronine Injection Warnings/Precautions

Warnings/Precautions

Ineffective for weight reduction in euthyroid patients. Not for treatment of infertility. Cardiovascular disease, angina, elderly: initiate therapy at 10–20micrograms. Severe and prolonged hypothyroidism. Fluid therapy. Adrenocortical insufficiency. Pregnancy. Nursing mothers.

Liothyronine Injection Pharmacokinetics

Metabolism

Hepatic. ~99.7% serum protein bound.

Elimination

Renal. Half-life: 1–2 days.

Liothyronine Injection Interactions

Interactions

Potentiates digitalis toxicity, tricyclic antidepressants, sympathomimetics (eg, anorectics). May increase risk of coronary insufficiency with vasopressors. Monitor oral anticoagulants, hypoglycemics. Estrogens affect thyroid function tests. May be potentiated by tricyclic antidepressants. Hypertension, tachycardia with ketamine.

Liothyronine Injection Adverse Reactions

Adverse Reactions

Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, MI, angina, CHF, hypertension, twitching.

Liothyronine Injection Clinical Trials

See Literature

Liothyronine Injection Note

Notes

Formerly known under the brand name Triostat.

Liothyronine Injection Patient Counseling