HUMALOG MIX50/50 Dosage & Rx Info

Humalog Mix50/50 Generic Name & Formulations

Legal Class

General Description

Insulin lispro protamine suspension 50% (rDNA origin), insulin lispro 50% (rDNA origin) 100 Units/mL; SC inj; contains zinc, m-cresol.

How Supplied

Humalog Mix75/25, Humalog Mix50/50, Humalog vials (10mL)—1; Humalog Mix, Humalog U-100 KwikPen (prefilled) (3mL), Humalog U-100 Tempo Pen (prefilled) (3mL), Humalog U-100 Junior KwikPen (prefilled) (3mL), Humalog U-200 KwikPen (prefilled) (3mL)—5; Humalog cartridges (3mL)—5; HumaPen LUXURA HD (inj device, uses Humalog cartridges)—1

Manufacturer

Eli Lilly and Company

Mechanism of Action

The primary activity of insulin including Humalog Mix50/50 is the regulation of glucose metabolism. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis.

Humalog Mix50/50 Indications

Indications

Diabetes.

Humalog Mix50/50 Dosage and Administration

Adult

≥18yrs: SC inj only. Onset approx ≤15mins, peak 1–5hrs, duration 11–22hrs.

Children

<18yrs: not established.

Humalog Mix50/50 Contraindications

Contraindications

During episodes of hypoglycemia.

Humalog Mix50/50 Boxed Warnings

Not Applicable

Humalog Mix50/50 Warnings/Precautions

Warnings/Precautions

Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Do not reuse or share pens, needles, cartridges, or syringes between patients, even if the needle is changed. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia of hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K⁺-lowering or K⁺-sensitive drugs). Discontinue if hypersensitivity reactions occur. Hyperglycemia and ketoacidosis due to insulin pump device malfunction: see full labeling. Pregnancy. Nursing mothers.

Humalog Mix50/50 Pharmacokinetics

Absorption

Median peak serum concentration: 60 minutes (range: 45 minutes to 2 hours) after dosing.

Metabolism

Hepatic.

Humalog Mix50/50 Interactions

Interactions

Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. When mixing insulin lispro with other insulins, draw insulin lispro into syringe first and inject mixture immediately.

Humalog Mix50/50 Adverse Reactions

Adverse Reactions

Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema.

Humalog Mix50/50 Clinical Trials

See Literature

Humalog Mix50/50 Note