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Glyset Generic Name & Formulations
Legal Class
Rx
General Description
Miglitol 25mg, 50mg, 100mg; tabs.
Pharmacological Class
Alpha-glucosidase inhibitor.
How Supplied
Tabs—100
Manufacturer
Generic Availability
NO
Glyset Indications
Indications
Adjunct to diet in type 2 diabetes, alone or with a sulfonylurea.
Glyset Dosage and Administration
Adult
Take with the first bite of each main meal. Initially 25mg three times daily; may start at 25mg once daily (to minimize GI effects) and gradually increase to 25mg three times daily. Increase to 50mg three times daily after 4–8 weeks; usual max 100mg three times daily.
Children
Not established.
Glyset Contraindications
Contraindications
Ketoacidosis. Inflammatory bowel disease. Colonic ulceration. Partial intestinal obstruction or predisposition thereof. Chronic intestinal diseases associated with marked disorders of digestion or absorption. Conditions that may deteriorate from increased intestinal gas formation.
Glyset Boxed Warnings
Not Applicable
Glyset Warnings/Precautions
Warnings/Precautions
Significant renal dysfunction (serum creatinine >2mg/dL): not recommended. Use glucose, not sucrose, to treat hypoglycemia. Stress. Monitor 1-hour postprandial blood glucose initially and during titration then glycosylated hemoglobin. Pregnancy (Cat.B): consider using insulin instead. Nursing mothers: not recommended.
Glyset Pharmacokinetics
See Literature
Glyset Interactions
Interactions
Antagonized by intestinal adsorbents (eg, charcoal), pancreatin, amylase, other carbohydrate-splitting enzymes. May decrease levels of ranitidine, propranolol. Risk of hypoglycemia with concomitant sulfonylureas or insulin; consider reducing dose of these.
Glyset Adverse Reactions
Adverse Reactions
Transient flatulence, diarrhea, abdominal pain; low serum iron.
Glyset Clinical Trials
See Literature
Glyset Note
Not Applicable
Glyset Patient Counseling
See Literature
