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Dexamethasone Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Dexamethasone 0.5mg/5mL.
Pharmacological Class
Glucocorticoid.
See Also
How Supplied
Soln—240mL, 500mL; Intensol—30mL (w. dropper)
Manufacturer
Dexamethasone Oral Solution Indications
Indications
Corticosteroid-responsive disorders.
Dexamethasone Oral Solution Dosage and Administration
Adult
See full labeling. Initally 0.75–9mg daily. Intensol: mix with liquid or semi-solid food.
Children
See full labeling. Initally 0.02–0.3mg/kg/day in 3–4 divided doses. Intensol: mix with liquid or semi-solid food.
Dexamethasone Oral Solution Contraindications
Contraindications
Systemic fungal infection. Live vaccination.
Dexamethasone Oral Solution Boxed Warnings
Not Applicable
Dexamethasone Oral Solution Warnings/Precautions
Warnings/Precautions
Cerebral malaria, optic neuritis, active ocular herpes simplex: not recommended. Strongyloides infestation. Tuberculosis. Latent or active amebiasis. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Recent MI. CHF. Hypertension. Renal insufficiency. Peptic ulcers. Diverticulitis. Intestinal anastomoses. Ulcerative colitis. Cirrhosis. Postmenopausal women (osteoporosis risk). Diabetes. Thyroid disorder. Myasthenia gravis. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Monitor thyroid, weight, growth, fluid, electrolyte balance and intraocular pressure (w. therapy >6wks). Pregnancy (Cat.C). Nursing mothers: not recommended.
Dexamethasone Oral Solution Pharmacokinetics
See Literature
Dexamethasone Oral Solution Interactions
Interactions
Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin), ephedrine. May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Increased GI effects with aspirin or other NSAIDs. Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics). Toxic epidermal necrolysis possible with thalidomide. Concomitant indomethacin: may get false-negative on dexamethasone suppression test. May suppress reactions to skin tests.
Dexamethasone Oral Solution Adverse Reactions
Adverse Reactions
HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, hyperglycemia.
Dexamethasone Oral Solution Clinical Trials
See Literature
Dexamethasone Oral Solution Note
Not Applicable
Dexamethasone Oral Solution Patient Counseling
See Literature
