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Cycloset Generic Name & Formulations
Legal Class
Rx
General Description
Bromocriptine mesylate (micronized) 0.8mg; tabs.
Pharmacological Class
Dopamine agonist (ergot deriv).
How Supplied
Tabs—200
Manufacturer
Cycloset Indications
Indications
Adjunct to diet and exercise, to improve glycemic control in type 2 diabetes.
Limitations of Use
Not for treating type 1 diabetes or ketoacidosis. Limited efficacy data in combination with thiazolidinediones. Efficacy has not been confirmed in combination with insulin.
Cycloset Dosage and Administration
Adult
Take with food in the AM, within 2hrs of waking. Initially 0.8mg once daily; may increase by 0.8mg per week as tolerated until max 4.8mg/day. Usual range: 1.6–4.8mg/day. Concomitant moderate CYP3A4 inhibitors (eg, erythromycin): max 1.6mg once daily. Concomitant strong CYP3A4 inhibitors (eg, azole antimycotics, protease inhibitors): avoid.
Children
Not established.
Cycloset Contraindications
Contraindications
Syncopal migraines. Postpartum or lactating patients. Allergy to ergot-related drugs.
Cycloset Boxed Warnings
Not Applicable
Cycloset Warnings/Precautions
Warnings/Precautions
Monitor orthostatic vital signs initially and periodically during therapy. Severe psychotic disorders: not recommended. Impulse control/compulsive behaviors. Renal or hepatic impairment. Postpartum patients with cardiovascular disease. Pregnancy.
Cycloset Pharmacokinetics
See Literature
Cycloset Interactions
Interactions
See Adult. Concomitant selective 5-HT1B agonists (eg, sumatriptan), sympathomimetic drugs >10 days, ergot-related drugs within 6hrs, other dopamine agonists and antagonists, including neuroleptics (eg, clozapine, olanzapine, ziprasidone) and metoclopramide: not recommended. Potentiated by CYP3A4 inhibitors and antagonized by CYP3A4 inducers (eg, rifampin, dexamethasone). Potentiates antihypertensives; caution. May potentiate highly protein bound drugs (eg, salicylates, sulfonamides, chloramphenicol, probenecid).
Cycloset Adverse Reactions
Adverse Reactions
Nausea, vomiting, fatigue, dizziness, headache; hypotension, syncope, somnolence, hypoglycemia.
Cycloset Clinical Trials
See Literature
Cycloset Note
Not Applicable
Cycloset Patient Counseling
See Literature
