Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Chlorpropamide Generic Name & Formulations
Legal Class
Rx
General Description
Chlorpropamide 100mg, 250mg; scored tabs.
Pharmacological Class
Sulfonylurea (1st generation).
How Supplied
Contact supplier
Manufacturer
Chlorpropamide Indications
Indications
Adjunct to diet in type 2 diabetes.
Chlorpropamide Dosage and Administration
Adult
Initially 250mg daily. Elderly: initially 100–125mg daily. Titrate dose. Take with breakfast. Max 750mg daily.
Children
Not recommended.
Chlorpropamide Contraindications
Contraindications
Type 1 diabetes mellitus. Diabetic ketoacidosis.
Chlorpropamide Boxed Warnings
Not Applicable
Chlorpropamide Warnings/Precautions
Warnings/Precautions
Oral hypoglycemic agents may increase risk of cardiovascular mortality. Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. G6PD deficiency. Monitor urine and blood glucose. Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider insulin instead. Nursing mothers: not recommended.
Chlorpropamide Pharmacokinetics
See Literature
Chlorpropamide Interactions
Interactions
Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers. Antagonized by diuretics, steroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, calcium channel blockers and isoniazid. Disulfiram-like reaction with alcohol.
Chlorpropamide Adverse Reactions
Adverse Reactions
Hypoglycemia, cholestatic jaundice, GI disturbances, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria.
Chlorpropamide Clinical Trials
See Literature
Chlorpropamide Note
Notes
Formerly known under the brand name Diabinese.
Chlorpropamide Patient Counseling
See Literature
