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Porcine Secretin Generic Name & Formulations
Legal Class
Rx
General Description
Porcine secretin 16mcg; per vial; lyophilized pwd for IV inj after reconstitution.
Pharmacological Class
Hormone.
How Supplied
Single-dose vial—1
Manufacturer
Generic Availability
NO
Porcine Secretin Indications
Indications
For the stimulation of pancreatic secretions, including bicarbonate to aid in the diagnosis of pancreatic exocrine dysfunction, and to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). For the stimulation of gastrin secretin to aid in the diagnosis of gastrinoma.
Porcine Secretin Dosage and Administration
Adult
See full labeling. Discontinue interacting drugs (eg, anticholinergics, H2-receptor antagonists, or PPIs) prior to testing accordingly; see Interactions. Administer IV test dose (0.2mcg); if no hypersensitivity reaction after 1min, give recommended dose as IV inj slowly over 1min. Exocrine pancreas dysfunction (fast for at least 12–15hrs prior to testing): 0.2mcg/kg. ERCP: 0.2mcg/kg. Gastrinoma (fast for at least 12hrs prior to testing): 0.4mcg/kg.
Children
Not established.
Porcine Secretin Contraindications
Contraindications
Acute hypersensitivity reaction to test dose. Documented hypersensitivity reaction to porcine products.
Porcine Secretin Boxed Warnings
Not Applicable
Porcine Secretin Warnings/Precautions
Warnings/Precautions
Stimulation testing should only be performed by physicians with sufficient expertise. Have appropriate resuscitative measures available. History of atopy. Undergone vagotomy, inflammatory bowel disease: may be hyporesponsive to stimulation. Alcoholic or other liver disease: may be hyperresponsive to stimulation. Pregnancy. Nursing mothers.
Porcine Secretin Pharmacokinetics
See Literature
Porcine Secretin Interactions
Interactions
Possible hyporesponse to stimulation testing with concomitant anticholinergics; discontinue at least 5 half-lives prior to testing. Possible hyperresponse with concomitant H2-receptor antagonists; discontinue at least 2 days prior to testing. Concomitant PPIs may cause hyperresponse to stimulation: refer to specific labeling prior to testing.
Porcine Secretin Adverse Reactions
Adverse Reactions
Abdominal discomfort, nausea, flushing, burning in stomach, diaphoresis, bradycardia, decreased BP.
Porcine Secretin Clinical Trials
See Literature
Porcine Secretin Note
Not Applicable
Porcine Secretin Patient Counseling
See Literature
