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Optison Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Single-patient use vials (3mL)—5, 18
Manufacturer
Generic Availability
NO
Mechanism of Action
Optison microspheres create an echogenic contrast effect in the blood. The acoustic impedance of the microspheres is much lower than that of the blood. Therefore, impinging ultrasound waves are scattered and reflected at the microsphere-blood interface and ultimately may be visualized in the ultrasound image.
Optison Indications
Indications
To opacify the left ventricle and to improve the delineation of the left ventricular endocardial borders in patients with suboptimal echocardiograms.
Optison Dosage and Administration
Adult
Give by IV inj into peripheral vein. Initially 0.5mL; may repeat doses in 0.5mL increments, if inadequate contrast enhancement. Max total dose: 5mL in any 10-min period or 8.7mL in any single patient study.
Children
Not established.
Optison Contraindications
Not Applicable
Optison Boxed Warnings
Boxed Warning
Serious cardiopulmonary reactions.
Optison Warnings/Precautions
Warnings/Precautions
Have resuscitation equipment readily available. Increased risk for serious cardiopulmonary reactions in those with unstable conditions (eg, acute MI, acute coronary artery syndromes, worsening or unstable CHF, serious ventricular arrhythmias). Monitor for acute and hypersensitivity reactions. Cardiac shunt; assess for embolic phenomena after administration. Mechanical indices >0.8: not recommended. Contains human albumin; risk for viral transmission (eg, Creutzfeldt-Jakob disease). Elderly. Pregnancy. Nursing mothers.
Optison Pharmacokinetics
Elimination
Pulmonary. Half-life: 1.3±0.69 minutes.
Optison Interactions
Not Applicable
Optison Adverse Reactions
Adverse Reactions
Headache, nausea, vomiting, warm sensation, flushing, dizziness; cardiopulmonary reactions (may be fatal), hypersensitivity reactions.
Optison Clinical Trials
See Literature
Optison Note
Not Applicable
Optison Patient Counseling
See Literature
