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Optiray 320 Generic Name & Formulations
Legal Class
Rx
General Description
Ioversol 678mg/mL; soln for intra-arterial or intravenous inj; contains organically bound iodine 320mg per mL.
Pharmacological Class
Radiopaque contrast agent.
See Also
How Supplied
OPTIRAY 300: Bottles (50mL)—25, 100mL, 150mL, 200mL—12, Syringes (50mL, 100mL)—20, RFID-Tagged syringes (100mL)—20; OPTIRAY 320: Vials (20mL, 30mL)—25, Bottles (50mL)—25, 100mL, 150mL, 200mL—12, Syringes (50mL, 75mL, 100mL, 125mL)—20, RFID-Tagged syringes (75mL, 100mL, 125mL)—20; OPTIRAY 350: Bottles (50mL)—25, 100mL, 150mL, 200mL—12, Syringes (50mL, 75mL, 100mL, 125mL)—20, RFID-Tagged syringes (50mL, 100mL, 125mL)—20
Manufacturer
Generic Availability
NO
Optiray 320 Indications
Indications
Adults: Cerebral, peripheral, visceral, renal and coronary arteriography. Aortography, left ventriculography. Computed tomography (CT) imaging of the head and body, venography, and intravenous (IV) excretory urography. Children: Angiocardiography. CT imaging of the head and body and IV excretory urography.
Optiray 320 Dosage and Administration
Adult
Individualize. Cerebral arteriography (carotid or vertebral arteries): 2–12mL; (aortic arch inj [four vessel study]): 20–50mL; both: may repeat as necessary; max 200mL. Peripheral arteriography (aortic-iliac runoff): 60mL (range 20–90mL); (common iliac, femoral): 40mL (range 10–50mL); (subclavian, brachial): 20mL (range 15–30mL); all: max 250mL. Visceral arteriography, renal arteriography, aortography (aorta): 45mL (range 10–80mL); (celiac): 45mL (range 12–60mL); (superior mesenteric): 45mL (range 15–60mL); (renal or inferior mesenteric): 9mL (range 6–15mL); all: max 250mL. Coronary arteriography and left ventriculography (left coronary): 8mL (range 2–10mL); (right coronary): 6mL (range 1–10mL); (left ventricle): 40mL (range 30–50mL); all: max 250mL. Venography: 50–100mL per extremity; max 250mL. CT (head): 50–150mL by infusion; (body): may give as 25–75mL bolus inj or 50–150mL by infusion, or combination of both. IV urography (usual dose): 50–75mL; (high dose): 1.5–2mL/kg; max 150mL.
Children
Angiocardiography: 1.25mL/kg (range 1–1.5mL/kg); max 5mL/kg up to max 250mL. CT (head and body): 1.5–2mL/kg (range 1–3mL/kg). IV urography: 1–1.5mL/kg (range 0.5–3mL/kg); max 3mL/kg.
Optiray 320 Contraindications
Contraindications
Symptomatic hyperthyroidism.
Optiray 320 Boxed Warnings
Boxed Warning
Risks with inadvertent intrathecal administration. For intra-arterial and intravenous use only.
Optiray 320 Warnings/Precautions
Warnings/Precautions
Inadvertent intrathecal administration; may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema. History of previous reactions to a contrast agent and known allergies (eg, bronchial asthma, drug, or food) and other hypersensitivities; monitor. Should be administered by professional trained in use of radiopaque agents in appropriate facilities with emergency treatment readily available. Monitor for severe cardiovascular reactions. Risk of serious thromboembolic events (eg, MI, stroke) during angiographic procedures. Avoid angiography with homocystinuria. CHF. Dehydration. Diabetes. Advanced vascular disease. Multiple myeloma or other paraproteinemia. Hyperthyroidism. Autonomous thyroid nodule. Thyroid dysfunction (esp. children 0–3yrs); monitor. Pheochromocytoma or catecholamine-secreting paraganglioma: monitor closely. Homozygous sickle cell disease. History of severe cutaneous adverse reactions (SCAR); avoid. Hepatic or renal impairment. Use lowest effective dose. Maintain adequate hydration. Avoid extravasation. Elderly. Pregnancy. Nursing mothers: consider interrupting, pumping, and discarding breast milk for 8hrs after Optiray.
Optiray 320 Pharmacokinetics
See Literature
Optiray 320 Interactions
Interactions
Increased risk of metformin-induced lactic acidosis; discontinue metformin at the time of, or prior to, Optiray in high risk patients (see full labeling). May antagonize radioactive iodine for thyroid carcinoma for up to 6–8wks. Defer in patients with hepatic impairment who recently received oral cholecystographic contrast agents. Caution with concomitant diuretics, nephrotoxic agents. Avoid laxatives, diuretics prior to administration. Protein-bound iodine or radioactive iodine uptake study results may not accurately reflect thyroid function for up to 16 days.
Optiray 320 Adverse Reactions
Adverse Reactions
Nausea; hypersensitivity reactions, acute kidney injury, cardiovascular reactions, SCAR (eg, SJS/TEN, DRESS). Also in children: fever.
Optiray 320 Clinical Trials
See Literature
Optiray 320 Note
Not Applicable
Optiray 320 Patient Counseling
See Literature
