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Netspot Generic Name & Formulations
Legal Class
Rx
General Description
Gallium Ga 68 dotatate 79.3–201.8MBq/mL (2.1–5.45mCi/mL); per kit; lyophilized pwd for IV inj after reconstitution and pH adjustment.
Pharmacological Class
Radioactive diagnostic agent.
How Supplied
Single-dose kit—1 (reaction vial w. lyophilized pwd + buffer vial)
Manufacturer
Generic Availability
NO
Netspot Indications
Indications
For use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs).
Netspot Dosage and Administration
Adults and Children
See full labeling. Give 2MBq/kg (0.054mCi/kg) up to 200MBq (5.4mCi), as a single IV bolus inj. Starting 40–90mins after IV inj, acquire PET image. The effective radiation dose from 150MBq (4.05mCi) dose is 3.15mSv (to an adult weighing 75kg).
Netspot Contraindications
Not Applicable
Netspot Boxed Warnings
Not Applicable
Netspot Warnings/Precautions
Warnings/Precautions
Risk of radiation exposure. Ensure adequate hydration. Should only be used by trained and experienced physicians in the safe use and handling of radionuclides to minimize radiation exposure. Avoid contact with infants, pregnant women during first 12hrs after administration. Risk for image misinterpretation and other errors. Pregnancy. Nursing mothers: interrupt for 12hrs after Netspot exposure.
Netspot Pharmacokinetics
See Literature
Netspot Interactions
Interactions
Concomitant long-acting somatostatin analogs: image with Netspot PET just prior to analog dosing. Concomitant short-acting somatostatin analogs: may be used up to 24hrs prior to imaging with Netspot. May result in false negative imaging with high doses of repeated glucocorticoid administration.
Netspot Adverse Reactions
Adverse Reactions
Nausea, vomiting, inj site pain, burning sensation; hypersensitivity reactions.
Netspot Clinical Trials
See Literature
Netspot Note
Not Applicable
Netspot Patient Counseling
See Literature
