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Myoview Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Kit—5 (multi-dose vials)
Manufacturer
Generic Availability
NO
Mechanism of Action
Technetium (99mTc) tetrofosmin is a lipophilic, cationic complex which diffuses passively through the cell membrane and is locally retained actively due to the presence of intact mitochondria reflecting the presence of viable cells. After IV injection, it is distributed within the myocardium according to myocardial perfusion and viability.
Myoview Indications
Indications
Myocardial perfusion imaging under rest and/or exercise or pharmacologic stress conditions to delineate regions of reversible myocardial ischemia or infarcted myocardium in patients with known or suspected coronary artery disease. For assessment of left ventricular function (LVEF and wall motion) in patients with known or suspected heart disease.
Myoview Dosage and Administration
Adult
See full labeling. Rest and stress imaging: give 185–1,221MBq (5–33mCi) as IV inj. When rest and stress IV inj (given on the same day): initially 185–444MBq (5–12mCi), followed by 555–1,221MBq (15–33mCi) given ~1–4hrs after. Ventricular function imaging: give 185–1,221MBq (5–33mCi) as IV inj.
Children
Not established.
Myoview Contraindications
Not Applicable
Myoview Boxed Warnings
Not Applicable
Myoview Warnings/Precautions
Warnings/Precautions
Have cardiopulmonary resuscitation equipment readily available. Risk for radiation exposure. Should only be used by trained and experienced physicians in the safe use and handling of radioactive materials to minimize radiation exposure. Ensure adequate hydration. Advise to void after exam, and frequently thereafter. Monitor for hypersensitivity reactions. Pregnancy. Nursing mothers: pump and discard breast milk for 60hrs after administration.
Myoview Pharmacokinetics
Elimination
Renal (~40%), fecal (~26%).
Myoview Interactions
Not Applicable
Myoview Adverse Reactions
Adverse Reactions
Angina, hypertension, torsades de pointes, vomiting, abdominal discomfort, cutaneous allergy, hypotension, dyspnea, metallic taste, burning of the mouth, smell alteration.
Myoview Clinical Trials
See Literature
Myoview Note
Not Applicable
Myoview Patient Counseling
See Literature
