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Metopirone Generic Name & Formulations
Legal Class
Rx
General Description
Metyrapone 250mg; caps.
Pharmacological Class
Adrenal corticosteroid synthesis inhibitor.
How Supplied
Caps—18
Manufacturer
Metopirone Indications
Indications
Diagnostic drug for testing hypothalamic-pituitary ACTH function.
Metopirone Dosage and Administration
Adult
Single-dose short test: 30mg/kg (max 3g) at midnight with yogurt or milk. Blood sample for assay taken early the following morning. Give prophylactic dose of cortisone acetate 50mg. Multiple-dose test: Testing done over 6-day period. Administer 750mg every 4 hours for 6 doses on Day 5. See literature for results interpretation.
Children
Single-dose short test: 30mg/kg (max 3g) at midnight with yogurt or milk. Blood sample for assay taken early the following morning. Give prophylactic dose of cortisone acetate 50mg. Multiple-dose test: Testing done over 6-day period. Administer 15mg/kg every 4 hours for 6 doses on Day 5. A minimum single dose of 250mg is recommended. See literature for results interpretation.
Metopirone Contraindications
Contraindications
Adrenal cortical insufficiency.
Metopirone Boxed Warnings
Not Applicable
Metopirone Warnings/Precautions
Warnings/Precautions
May induce acute adrenal insufficiency in patients with reduced adrenal secretory capacity. Hypo- or hyperthyroidism. Pregnancy (Cat.C). Nursing mothers.
Metopirone Pharmacokinetics
See Literature
Metopirone Interactions
Interactions
Discontinue drugs affecting pituitary and adrenocortical function prior to and during testing. May be antagonized by phenytoin; test may be inaccurate in patients taking phenytoin 2 weeks prior. Subnormal response with estrogen therapy. May potentiate acetaminophen toxicity.
Metopirone Adverse Reactions
Adverse Reactions
Hypotension, GI upset, abdominal pain, headache, dizziness, sedation, rash; rare: decreased WBC, bone marrow depression.
Metopirone Clinical Trials
See Literature
Metopirone Note
Not Applicable
Metopirone Patient Counseling
See Literature
