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Magnevist Generic Name & Formulations
Legal Class
Rx
General Description
Gadopentetate dimeglumine 469.01mg/mL (0.5mmol/mL); soln for IV inj; preservative-free.
Pharmacological Class
Gadolinium-based contrast agent.
How Supplied
Single-dose vials (5mL, 10mL, 15mL, 20mL)—20; Pre-filled syringes (10mL, 15mL, 20mL)—5
Manufacturer
Magnevist Indications
Indications
For use in MRI of the brain (intracranial lesions), spine and associated tissues, of the head and neck, and of the body (excluding the heart) in adults and children to visualize lesions with abnormal vascularity.
Magnevist Dosage and Administration
Adults and Children
<2yrs: not established. Give by IV inj at a rate of max 10mL/15secs. ≥2yrs: 0.2mL/kg (0.1mmol/kg), followed by 5mL normal saline flush to ensure complete injection. >286lbs: dose not established.
Magnevist Contraindications
Contraindications
Chronic, severe kidney disease (GFR<30mL/min/1.73m2). Acute kidney injury.
Magnevist Boxed Warnings
Boxed Warning
Nephrogenic systemic fibrosis.
Magnevist Warnings/Precautions
Warnings/Precautions
Increased risk of nephrogenic systemic fibrosis in chronic kidney disease or acute kidney injury (see Contraindications). Screen for renal dysfunction. Do not exceed recommended dose and allow sufficient time for drug elimination before re-administration. Have emergency resuscitative equipment available. History of asthma or other allergic disorders. Monitor for signs/symptoms of hypersensitivity reactions during and up to several hrs after administration. Increased risk of gadolinium retention with multiple lifetime doses, in pregnant patients, children, and those with inflammatory conditions; minimize repetitive imaging studies. Renal impairment: use lowest effective dose. Avoid extravasation. Interpreting Magnevist MRI scans without a companion non-contrast MRI. Elderly. Pregnancy. Nursing mothers.
Magnevist Pharmacokinetics
See Literature
Magnevist Interactions
Not Applicable
Magnevist Adverse Reactions
Adverse Reactions
Headache, nausea, inj site coldness/localized coldness, dizziness; hypersensitivity reactions; rare: inj site reactions.
Magnevist Clinical Trials
See Literature
Magnevist Note
Not Applicable
Magnevist Patient Counseling
See Literature
