Lipiodol

— THERAPEUTIC CATEGORIES —
  • Imaging agents
PAGE CONTENTS
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  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Lipiodol Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Ethiodized oil 480mg/mL; oil for intralymphatic, intrauterine or intra-arterial inj; contains organically combined iodine with ethyl esters of fatty acids of poppy seed oil.

    Pharmacological Class

    Radiopaque contrast agent.

    How Supplied

    Ampoule (10mL)—1

    Manufacturer

    Guerbet LLC

    Generic Availability

    NO

    Mechanism of Action

    Lipiodol opacifies vessels and body structures in the path of the flow of the contrast medium, permitting visualization of the internal structures.

    Lipiodol Indications

    Indications

    For use in: hysterosalpingography in adults, selective hepatic intra-arterial use for imaging tumors in adults with hepatocellular carcinoma (HCC), or lymphography in children and adults.

    Lipiodol Dosage and Administration

    Adult

    See full labeling. Hysterosalpingography: inject in 2mL increments into endometrial cavity with fluoroscopic control until tubal patency determined; re-image after 24hrs to establish contrast agent has entered peritoneal cavity. Lymphography: inject into lymphatic vessel over ≥1.25hrs (max rate 0.2mL/min) under radiologic monitoring; re-image after 24 or 48hrs to evaluate nodal architecture; (upper extremities): inject 2–4mL; (lower extremities): 6–8mL; (penile): 2–3mL; (cervical): 1–2mL. HCC: inject 1.5–15mL (based on tumor size) slowly under radiologic monitoring; discontinue when stagnation or reflux evident; max dose 20mL.

    Children

    See full labeling. Lymphography: inject 1–6mL according to anatomical area; max 0.25mL/kg.

    Lipiodol Contraindications

    Contraindications

    Hysterosalpingography: pregnancy, intrauterine bleeding and endocervicitis, acute pelvic inflammatory disease, marked cervical erosion, immediate pre- or postmenstrual phase or within 30 days of curettage or conization or known or suspected reproductive tract neoplasia. Lymphography: right to left cardiac shunt, advanced pulmonary disease, tissue trauma or hemorrhage advanced neoplastic disease with expected lymphatic obstruction, previous surgery interrupting the lymphatic system, radiation therapy to examined area. HCC: areas of liver where bile ducts are dilated unless external biliary drainage performed prior to injection. For all: hyperthyroidism, traumatic injuries, and recent hemorrhage or bleeding.

    Lipiodol Boxed Warnings

    Boxed Warning

    For intralymphatic, intrauterine and selective hepatic intra-arterial use only.

    Lipiodol Warnings/Precautions

    Warnings/Precautions

    Severely impaired lung function, cardiorespiratory failure, right-sided cardiac overload, sensitivity to other iodinated contrast agents, bronchial asthma, allergic disorders: avoid. Perform radiological monitoring during injection. Avoid intravasation. Monitor for hypersensitivity reactions during and for ≥30mins after administration. Exacerbation of portal hypertension, hepatic ischemia, hepatic failure. Do not exceed recommended dose. Monitor thyroid function for several months after completion. Screen for renal dysfunction prior to intra-arterial use; consider follow-up assessments if history of renal dysfunction. Pregnancy; exclude status within 24hrs prior to initiation (for hysterosalpingography). Nursing mothers: consider thyroid function testing.

    Lipiodol Pharmacokinetics

    See Literature

    Lipiodol Interactions

    Interactions

    May interfere with iodine-based diagnostic tests and radiotherapy.

    Lipiodol Adverse Reactions

    Adverse Reactions

    Hypersensitivity reactions, pulmonary embolism, pulmonary dysfunction, exacerbation of liver disease, procedural complications, abdominal pain, fever, nausea, vomiting, thyroid dysfunction.

    Lipiodol Clinical Trials

    See Literature

    Lipiodol Note

    Not Applicable

    Lipiodol Patient Counseling

    See Literature

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