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Kinevac Generic Name & Formulations
Legal Class
Rx
General Description
Sincalide 5mcg; per vial; lyophilized pwd for IV inj after reconstitution; contains sodium metabisulfite.
Pharmacological Class
Cholecystopancreatic-gastrointestinal hormone peptide.
How Supplied
Vials—10
Manufacturer
Generic Availability
NO
Mechanism of Action
When injected intravenously, sincalide stimulates gallbladder contraction and reduction in size. The evacuation of bile that results is similar to that which occurs physiologically in response to endogenous cholecystokinin. Sincalide also stimulates pancreatic secretion and intestinal motility causing pyloric contraction and slows gastric emptying.
Kinevac Indications
Indications
To stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals. To stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology. To accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract.
Kinevac Dosage and Administration
Adult
Give by IV inj. Gallbladder contraction: 0.02mcg/kg over 30–60secs; if unsatisfactory contraction after 15mins, may give second dose of 0.04mcg/kg. Pancreatic function test: 0.02mcg/kg infused over 30mins (start 30mins after secretin infusion). Barium meal transit: 0.04mcg/kg over 30–60secs; if unsatisfactory transit of barium meal after 30mins, may give second dose of 0.04mcg/kg.
Children
Not established.
Kinevac Contraindications
Contraindications
Intestinal obstruction. Hypersensitivity to sulfites.
Kinevac Boxed Warnings
Not Applicable
Kinevac Warnings/Precautions
Warnings/Precautions
Have appropriate medical treatment readily available. Monitor for hypersensitivity reactions; discontinue if occur and do not restart. Asthma. Small gallbladder stones (risk of lodging in cystic duct or common bile duct; rare). Pregnancy; spontaneous abortion or premature induction of labor may occur. Nursing mothers.
Kinevac Pharmacokinetics
See Literature
Kinevac Interactions
Interactions
Drugs that affect gallbladder motility or contractile response may interfere with response to sincalide; consider discontinuing these drugs prior to Kinevac administration.
Kinevac Adverse Reactions
Adverse Reactions
Abdominal discomfort/pain, nausea; anaphylaxis, other hypersensitivity reactions.
Kinevac Clinical Trials
See Literature
Kinevac Note
Not Applicable
Kinevac Patient Counseling
See Literature
