Isovue-m 200 Generic Name & Formulations
Legal Class
Rx
General Description
Iopamidol 408mg/mL; soln for intrathecal administration; contains sodium 0.029mg, organically bound iodine 200mg per mL.
Pharmacological Class
Contrast media.
See Also
How Supplied
ISOVUE-M 200: Single dose vials (10mL)—10; ISOVUE-M 300: Single dose vials (15mL)—10
Manufacturer
Isovue-m 200 Indications
Indications
For intrathecal administration in adult neuroradiology inculding myelography (lumbar, thoracic, cervical, total columnar), and for contrast enhancement of computed tomographic (CECT) cisternography and ventriculography. For thoraco-lumbar myelography in children ≥2 years of age.
Isovue-m 200 Dosage and Administration
Adults and Children
See full labeling regarding dosing based on procedure.
Isovue-m 200 Contraindications
Contraindications
Concomitant corticosteroids. Repeat myelography in the event of technical failure. Significant local or systemic infections where bacteremia is likely.
Isovue-m 200 Boxed Warnings
Not Applicable
Isovue-m 200 Warnings/Precautions
Warnings/Precautions
Should be administered by professional trained in use of radiopaque agents in appropriate facilities with emergency treatment readily available. Increased intracranial pressure. Intracranial tumor. Abscess. Hematoma. History of convulsive disorder. Severe cardiovascular disease. Chronic alcoholism. Multiple sclerosis. Homozygous sickle cell disease. Multiple myeloma. Pheochromocytoma. Hyperthyroidism. Thyroid dysfunction (esp. children 0–3yrs); monitor. Diabetes. Patients with evidence of inadvertant intracranial entry of large or concentrated bolus of contrast medium: increased risk of seizures; consider prophylactic diazepam or barbiturate therapy. Direct intracisternal or ventricular administration for standard radiography: not recommended. Maintain elevation of head during procedure, on the stretcher, or in bed. Avoid excessive and active patient movement or straining. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.
Isovue-m 200 Pharmacokinetics
Elimination
Renal. Half-life: ~2 hours.
Isovue-m 200 Interactions
Interactions
Concomitant drugs that lower seizure threshold (eg, phenothiazines, MAOIs, tricyclics, CNS stimulants, analeptics, major tranquilizers, antipsychotics): not recommended; discontinue 48hrs and for at least 24hrs post-procedure. May reduce iodine-binding capacity of thyroid tissue for up to 2 weeks.
Isovue-m 200 Adverse Reactions
Adverse Reactions
Headache, GI upset, back pain, leg pain, neck pain, hypotension, others.
Isovue-m 200 Clinical Trials
See Literature
Isovue-m 200 Note
Not Applicable
Isovue-m 200 Patient Counseling
See Literature