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Glucagon Generic Name & Formulations
Legal Class
Rx
General Description
Glucagon (recombinant) 1mg/mL; lyophilized pwd for IM, IV, or SC inj after reconstitution.
Pharmacological Class
Antihypoglycemic.
How Supplied
Emergency kit (1mg)—1 (w. diluent)
Manufacturer
Glucagon Indications
Indications
Severe hypoglycemia in diabetics.
Glucagon Dosage and Administration
Adults and Children
Give by IM, IV, or SC inj. Administer IM or SC inj into upper arm, thigh or buttocks. <20kg: 0.5mg or 0.02–0.03mg/kg. ≥20kg: 1mg. May repeat in 15mins as needed. After responding and able to swallow, give oral carbohydrates.
Glucagon Contraindications
Contraindications
Pheochromocytoma. Insulinoma. Glucagonoma when used as a diagnostic test.
Glucagon Boxed Warnings
Not Applicable
Glucagon Warnings/Precautions
Warnings/Precautions
Instruct caregivers in proper use. Previously undiagnosed pheochromocytoma; risk of substantial increase in BP. If hypoglycemia develops after treatment, give oral or IV glucose. Conditions with insufficient hepatic glycogen (eg, starvation, adrenal insufficiency, chronic hypoglycemia); treat with glucose. Necrolytic migratory erythema (w. continuous infusion). As a diagnostic aid in diabetes or patients with cardiac disease; monitor blood glucose levels, BP, HR. Pregnancy. Nursing mothers.
Glucagon Pharmacokinetics
See Literature
Glucagon Interactions
Interactions
Transient increase in pulse and blood pressure may occur with beta-blockers. Loss of efficacy or may produce hypoglycemia with indomethacin. May potentiate the anticoagulant effect of warfarin. Potentiates anticholinergics; avoid concomitant use (during use as a diagnostic aid). Antagonized by insulin; monitor blood glucose (during use as a diagnostic aid).
Glucagon Adverse Reactions
Adverse Reactions
Inj site reactions, nausea, vomiting, headache, dizziness, asthenia, pallor, diarrhea, somnolence, decreased BP.
Glucagon Clinical Trials
See Literature
Glucagon Note
Not Applicable
Glucagon Patient Counseling
See Literature
Glucagon Generic Name & Formulations
Legal Class
Rx
General Description
Glucagon (recombinant) 1mg/mL; lyophilized pwd for IM, IV, or SC inj after reconstitution.
Pharmacological Class
Diagnostic aid.
How Supplied
Emergency kit (1mg)—1 (w. diluent)
Manufacturer
Glucagon Indications
Indications
For use during radiologic examinations to temporarily inhibit movement of the GI tract.
Glucagon Dosage and Administration
Adult
To relax the stomach, duodenum, small bowel: usually 0.25–0.5mg IV or 1mg IM; up to 2mg IV or IM may be used, if needed. Stomach: 0.5mg IV or 2mg IM. Colon: 2mg IM, given approx. 10mins prior to procedure. After procedure, give oral carbohydrates to patients who have been fasting, if compatible.
Children
Not established.
Glucagon Contraindications
Contraindications
Pheochromocytoma. Insulinoma. Glucagonoma when used as a diagnostic test.
Glucagon Boxed Warnings
Not Applicable
Glucagon Warnings/Precautions
Warnings/Precautions
Instruct caregivers in proper use. Previously undiagnosed pheochromocytoma; risk of substantial increase in BP. If hypoglycemia develops after treatment, give oral or IV glucose. Conditions with insufficient hepatic glycogen (eg, starvation, adrenal insufficiency, chronic hypoglycemia); treat with glucose. Necrolytic migratory erythema (w. continuous infusion). As a diagnostic aid in diabetes or patients with cardiac disease; monitor blood glucose levels, BP, HR. Pregnancy. Nursing mothers.
Glucagon Pharmacokinetics
See Literature
Glucagon Interactions
Interactions
Transient increase in pulse and blood pressure may occur with beta-blockers. Loss of efficacy or may produce hypoglycemia with indomethacin. May potentiate the anticoagulant effect of warfarin. Potentiates anticholinergics; avoid concomitant use (during use as a diagnostic aid). Antagonized by insulin; monitor blood glucose (during use as a diagnostic aid).
Glucagon Adverse Reactions
Adverse Reactions
Inj site reactions, nausea, vomiting, headache, dizziness, asthenia, pallor, diarrhea, somnolence, decreased BP.
Glucagon Clinical Trials
See Literature
Glucagon Note
Not Applicable
Glucagon Patient Counseling
See Literature
