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Glucagen Generic Name & Formulations
Legal Class
Rx
General Description
Glucagon (as HCl) (recombinant) 1mg; pwd for SC, IV, or IM inj after reconstitution.
Pharmacological Class
Antihypoglycemic.
How Supplied
HypoKit—1 (w. syringe + diluent)
Manufacturer
Glucagen Indications
Indications
Severe hypoglycemia in diabetics.
Glucagen Dosage and Administration
Adults and Children
Give by IM, SC, or IV inj. Administer IM or SC inj into upper arm, thigh or buttocks. Hypoglycemia: <25kg or <6yrs (with unknown weight): 0.5mg. ≥25kg or ≥6yrs (with unknown weight): 1mg. May repeat dose if no response after 15mins. After responding and able to swallow, give oral carbohydrates.
Glucagen Contraindications
Contraindications
Pheochromocytoma. Insulinoma. Glucagonoma when used as a diagnostic test.
Glucagen Boxed Warnings
Not Applicable
Glucagen Warnings/Precautions
Warnings/Precautions
Instruct caregivers in proper use. Previously undiagnosed pheochromocytoma; risk of substantial increase in BP. If hypoglycemia develops after treatment, give oral or IV glucose. Conditions with insufficient hepatic glycogen (eg, starvation, adrenal insufficiency, chronic hypoglycemia); treat with glucose. Necrolytic migratory erythema (w. continuous infusion). As a diagnostic aid in diabetes or patients with cardiac disease; monitor blood glucose levels, BP, HR. Pregnancy. Nursing mothers.
Glucagen Pharmacokinetics
See Literature
Glucagen Interactions
Interactions
Transient increase in pulse and blood pressure may occur with beta-blockers. Loss of efficacy or may produce hypoglycemia with indomethacin. May potentiate the anticoagulant effect of warfarin. Potentiates anticholinergics; avoid concomitant use (during use as a diagnostic aid). Antagonized by insulin; monitor blood glucose (during use as a diagnostic aid).
Glucagen Adverse Reactions
Adverse Reactions
Inj site reactions, nausea, vomiting, headache, dizziness, asthenia, pallor, diarrhea, somnolence, decreased BP.
Glucagen Clinical Trials
See Literature
Glucagen Note
Not Applicable
Glucagen Patient Counseling
See Literature
Glucagen Generic Name & Formulations
Legal Class
Rx
General Description
Glucagon (as HCl) (recombinant) 1mg; pwd for SC, IV, or IM inj after reconstitution.
Pharmacological Class
Diagnostic aid.
How Supplied
Diagnostic kit—1 (w. diluent); Single-dose vials—10
Manufacturer
Glucagen Indications
Indications
For use during radiologic examinations to temporarily inhibit movement of the GI tract.
Glucagen Dosage and Administration
Adult
To relax the stomach, duodenal bulb, duodenum, small bowel: 0.2–0.5mg IV or 1mg IM. To relax the colon: 0.5–0.75mg IV or 1–2mg IM. After procedure, give oral carbohydrates to patients who have been fasting, if compatible.
Children
Not established.
Glucagen Contraindications
Contraindications
Pheochromocytoma. Insulinoma. Glucagonoma when used as a diagnostic test.
Glucagen Boxed Warnings
Not Applicable
Glucagen Warnings/Precautions
Warnings/Precautions
Instruct caregivers in proper use. Previously undiagnosed pheochromocytoma; risk of substantial increase in BP. If hypoglycemia develops after treatment, give oral or IV glucose. Conditions with insufficient hepatic glycogen (eg, starvation, adrenal insufficiency, chronic hypoglycemia); treat with glucose. Necrolytic migratory erythema (w. continuous infusion). As a diagnostic aid in diabetes or patients with cardiac disease; monitor blood glucose levels, BP, HR. Pregnancy. Nursing mothers.
Glucagen Pharmacokinetics
See Literature
Glucagen Interactions
Interactions
Transient increase in pulse and blood pressure may occur with beta-blockers. Loss of efficacy or may produce hypoglycemia with indomethacin. May potentiate the anticoagulant effect of warfarin. Potentiates anticholinergics; avoid concomitant use (during use as a diagnostic aid). Antagonized by insulin; monitor blood glucose (during use as a diagnostic aid).
Glucagen Adverse Reactions
Adverse Reactions
Inj site reactions, nausea, vomiting, headache, dizziness, asthenia, pallor, diarrhea, somnolence, decreased BP.
Glucagen Clinical Trials
See Literature
Glucagen Note
Not Applicable
Glucagen Patient Counseling
See Literature
