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Datscan Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Single-dose vial (2.5mL)—1
Manufacturer
Generic Availability
NO
Mechanism of Action
Ioflupane binds reversibly to the human dopamine transporter (DaT). Following administration in humans, radioactive decay of the iodine-123 emits gamma radiation which can be detected externally using gamma detectors, allowing visualization of the brain striata through SPECT imaging.
Datscan Indications
Indications
As an adjunct to other diagnostic evaluations for striatal dopamine transporter visualization using single photon emission computed tomography (SPECT) brain imaging in adults with suspected Parkinsonian syndromes (PS) or suspected dementia with Lewy bodies (DLB).
Datscan Dosage and Administration
Adult
Administer potassium iodide oral solution or strong iodine solution (equivalent to 100mg iodide) at least 1hr prior to dose. Give by IV inj over ≥20secs. 111–185MBq (3–5mCi). Begin SPECT imaging 3–6hrs post-inj: see full labeling.
Children
Not established.
Datscan Contraindications
Not Applicable
Datscan Boxed Warnings
Not Applicable
Datscan Warnings/Precautions
Warnings/Precautions
Risk for radiation exposure. Should only be used by trained and experienced physicians in the safe use and handling of radionuclides to minimize radiation exposure. Ensure adequate hydration; encourage frequent voiding for first 48hrs post-administration. Have resuscitation equipment/medications readily available. Increased risk for thyroid neoplasia. Severe renal impairment. Pregnancy: exclude status prior to initiation (give thyroid blocking agent prior to inj). Nursing mothers: pump/discard breastmilk for ≥6 days after administration.
Datscan Pharmacokinetics
Elimination
Renal (60%), fecal (14%). Half-life: 13.2 hours.
Datscan Interactions
Interactions
Risk of image interference with concomitant drugs that bind to the dopamine transporter (eg, amoxapine, amphetamine, armodafinil, benztropine, bupropion, buspirone, cocaine, mazindol, methamphetamine, methylphenidate, modafinil, norephedrine, phentermine, phenylpropanolamine, selegiline, sertraline). May be potentiated or antagonized by concomitant SSRIs (eg, paroxetine, citalopram).
Datscan Adverse Reactions
Adverse Reactions
Headache, nausea, vertigo, dry mouth, dizziness; hypersensitivity reactions.
Datscan Clinical Trials
See Literature
Datscan Note
Not Applicable
Datscan Patient Counseling
See Literature
