Tremfya

— THERAPEUTIC CATEGORIES —
  • Arthritis/rheumatic disorders
  • Psoriasis

Tremfya Generic Name & Formulations

General Description

Guselkumab 100mg/mL; soln for SC inj; preservative-free.

Pharmacological Class

Interleukin-23 antagonist.

How Supplied

Single-dose prefilled syringe—1; Single-dose One-Press injector—1

Manufacturer

Generic Availability

NO

Tremfya Indications

Indications

Active psoriatic arthritis.

Tremfya Dosage and Administration

Adult

≥18yrs: 100mg by SC inj at Weeks 0 and 4, then every 8 weeks thereafter. May be given alone or in combination with a conventional DMARD (eg, methotrexate).

Children

<18yrs: not established.

Tremfya Contraindications

Not Applicable

Tremfya Boxed Warnings

Not Applicable

Tremfya Warnings/Precautions

Warnings/Precautions

Use under physician supervision. May increase risk of infections. Active infection: do not initiate until resolved. Chronic or history of recurrent infection: consider the risks and benefits. If a serious infection develops or is not responding to standard therapy, monitor closely and discontinue until resolved. Evaluate for tuberculosis (TB) infection and treat latent TB prior to initiating. Monitor for active TB during and after therapy. History of latent or active TB (without confirmed adequate treatment); consider anti-TB therapy prior to initiation. Discontinue and treat if serious hypersensitivity reactions occur. Consider completion of all age appropriate immunizations based on current guidelines prior to initiating. Pregnancy. Nursing mothers.

Tremfya Pharmacokinetics

See Literature

Tremfya Interactions

Interactions

Concomitant live vaccines: not recommended. Concomitant CYP450 substrates with narrow therapeutic index: monitor and adjust dose as needed.

Tremfya Adverse Reactions

Adverse Reactions

Upper respiratory infections, headache, inj site reactions, arthralgia, bronchitis, diarrhea, gastroenteritis, tinea infections, herpes simplex infections; hypersensitivty reactions.

Tremfya Clinical Trials

See Literature

Tremfya Note

Not Applicable

Tremfya Patient Counseling

See Literature

Tremfya Generic Name & Formulations

General Description

Guselkumab 100mg/mL; soln for SC inj; preservative-free.

Pharmacological Class

Interleukin-23 antagonist.

How Supplied

Single-dose prefilled syringe—1; Single-dose One-Press injector—1

Manufacturer

Generic Availability

NO

Tremfya Indications

Indications

Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Tremfya Dosage and Administration

Adult

≥18yrs: 100mg by SC inj at Weeks 0 and 4, then every 8 weeks thereafter.

Children

<18yrs: not established.

Tremfya Contraindications

Not Applicable

Tremfya Boxed Warnings

Not Applicable

Tremfya Warnings/Precautions

Warnings/Precautions

Use under physician supervision. May increase risk of infections. Active infection: do not initiate until resolved. Chronic or history of recurrent infection: consider the risks and benefits. If a serious infection develops or is not responding to standard therapy, monitor closely and discontinue until resolved. Evaluate for tuberculosis (TB) infection and treat latent TB prior to initiating. Monitor for active TB during and after therapy. History of latent or active TB (without confirmed adequate treatment); consider anti-TB therapy prior to initiation. Discontinue and treat if serious hypersensitivity reactions occur. Consider completion of all age appropriate immunizations based on current guidelines prior to initiating. Pregnancy. Nursing mothers.

Tremfya Pharmacokinetics

See Literature

Tremfya Interactions

Interactions

Concomitant live vaccines: not recommended. Concomitant CYP450 substrates with narrow therapeutic index: monitor and adjust dose as needed.

Tremfya Adverse Reactions

Adverse Reactions

Upper respiratory infections, headache, inj site reactions, arthralgia, bronchitis, diarrhea, gastroenteritis, tinea infections, herpes simplex infections; hypersensitivty reactions.

Tremfya Clinical Trials

See Literature

Tremfya Note

Not Applicable

Tremfya Patient Counseling

See Literature

Images