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Sulfamylon 5% Topical Solution Generic Name & Formulations
Legal Class
Rx
General Description
Mafenide acetate 50g/packet; pwd for reconstitution (5% soln after mixing).
Pharmacological Class
Antibacterial.
See Also
How Supplied
Crm—2oz, 4oz, 16oz
Packets—5
Packets—5
Manufacturer
Sulfamylon 5% Topical Solution Indications
Indications
Adjunct to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Sulfamylon 5% Topical Solution Dosage and Administration
Adults and Children
<3months: not recommended. ≥3months: Cover grafted area with one layer of fine mesh gauze. Cut an eight-ply burn dressing to the size of graft, wet with solution using an irrigation syringe and/or tubing until noticeable leaking. Maintain moisture with irrigation tubing (see literature) or wet dressing every 6–8 hours as needed. May leave wound dressings undisturbed for up to 5 days, except when irrigating. Additional soaks may be initiated until graft take is complete. Continue treatment until autograft vascularization and healing is progressing (approx. 5 days). Individual grafting procedure: max 5 days. Withhold therapy for 24–48 hours if acidosis occurs.
Sulfamylon 5% Topical Solution Contraindications
Contraindications
Sulfonamide allergy.
Sulfamylon 5% Topical Solution Boxed Warnings
Not Applicable
Sulfamylon 5% Topical Solution Warnings/Precautions
Warnings/Precautions
G6PD deficiency. Sulfite sensitivity. Asthma. Acute renal failure. Monitor acid-base balance closely (esp. with extensive 2nd degree or partial thickness burns, pulmonary or renal impairment). Pregnancy (Cat.C); (crm: not recommended for women of childbearing potential; unless burn area >20% of total body surface). Nursing mothers: not recommended.
Sulfamylon 5% Topical Solution Pharmacokinetics
See Literature
Sulfamylon 5% Topical Solution Interactions
Not Applicable
Sulfamylon 5% Topical Solution Adverse Reactions
Adverse Reactions
Application-site pain, burning sensation, allergic manifestations (eg, rash, pruritus, facial edema, swelling, erythema; discontinue if occur), tachypnea, hyperventilation, metabolic acidosis; respiratory alkalosis, fatal hemolytic anemia with disseminated intravascular coagulation, fungal colonization; rare: excoriation of new skin, bleeding of skin.
Sulfamylon 5% Topical Solution Clinical Trials
See Literature
Sulfamylon 5% Topical Solution Note
Not Applicable
Sulfamylon 5% Topical Solution Patient Counseling
See Literature
