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Solodyn Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline (as HCl) 55mg, 65mg, 80mg, 105mg, 115mg; ext-rel tabs.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Ext-rel tabs—30
Manufacturer
Solodyn Indications
Indications
Inflammatory lesions of non-nodular moderate to severe acne.
Solodyn Dosage and Administration
Adult
Swallow whole. Give approximately 1mg/kg once daily for 12wks. Weight-based dosing (45–49kg): 45mg; (50–59kg): 55mg; (60–71kg): 65mg; (72–84kg): 80mg; (85–96kg): 90mg; (97–110kg): 105mg; (111–125kg): 115mg; (126–136kg): 135mg. Renal impairment: reduce dose or extend dosing intervals.
Children
<12yrs: not established.
Solodyn Contraindications
Not Applicable
Solodyn Boxed Warnings
Not Applicable
Solodyn Warnings/Precautions
Warnings/Precautions
Not bioequivalent with other minocycline products. Monitor blood, renal, and hepatic function. Discontinue if superinfection, DRESS syndrome, or autoimmune syndromes develop. Monitor for visual disturbances. Renal or hepatic impairment. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.
Solodyn Pharmacokinetics
See Literature
Solodyn Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. May interfere with fluorescence test.
Solodyn Adverse Reactions
Adverse Reactions
Headache, fatigue, dizziness, pruritus; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hyperpigmentation, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Solodyn Clinical Trials
See Literature
Solodyn Note
Not Applicable
Solodyn Patient Counseling
See Literature
