Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Silvadene Generic Name & Formulations
Legal Class
Rx
General Description
Silver sulfadiazine 1%; cream.
Pharmacological Class
Sulfonamide antibacterial.
How Supplied
Crm—20g, 50g, 85g, 400g, 1000g
Manufacturer
Silvadene Indications
Indications
Prophylaxis and treatment of sepsis in 2nd and 3rd degree burns.
Silvadene Dosage and Administration
Adult
Apply 1–2 times daily aseptically to approximately 1/16 inch depth to cleansed and debrided burns. Reapply promptly if removed. Continue until wound closed.
Children
Not established.
Silvadene Contraindications
Contraindications
Premature infants. Within first 2 months of birth. Late pregnancy.
Silvadene Boxed Warnings
Not Applicable
Silvadene Warnings/Precautions
Warnings/Precautions
G6PD deficiency. Impaired renal or hepatic function. Monitor serum sulfa levels and renal function in extensive burns. Avoid eyes. Pregnancy (Cat.B). Nursing mothers: not recommended.
Silvadene Pharmacokinetics
See Literature
Silvadene Interactions
Interactions
Leukopenia increased with concomitant cimetidine. May inactivate debriding enzymes.
Silvadene Adverse Reactions
Adverse Reactions
Transient leukopenia, skin necrosis, erythema multiforme, skin discoloration, burning sensation, rash, pruritus, interstitial nephritis, reduction in bacterial growth; systemic sulfonamide reactions, fungal overgrowth.
Silvadene Clinical Trials
See Literature
Silvadene Note
Not Applicable
Silvadene Patient Counseling
See Literature
