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Siliq Generic Name & Formulations
Legal Class
Rx
General Description
Brodalumab 210mg/1.5mL; soln for SC inj; preservative-free.
Pharmacological Class
Interleukin-17A antagonist.
How Supplied
Single-dose prefilled syringes—2
Manufacturer
Generic Availability
NO
Siliq Indications
Indications
Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy and unresponsive to other systemic therapies.
Siliq Dosage and Administration
Adult
Give by SC inj into thigh, abdomen (except for area around navel), outer area of upper arm; rotate inj sites. 210mg at Weeks 0, 1, and 2 followed by 210mg every 2 weeks. If adequate response not achieved after 12–16 weeks, consider discontinuing.
Children
Not established.
Siliq Contraindications
Contraindications
Crohn’s disease.
Siliq Boxed Warnings
Boxed Warning
Suicidal ideation and behavior.
Siliq Warnings/Precautions
Warnings/Precautions
Risk of suicidal ideation and behavior. History of depression or suicidality. May increase risk of infections. Chronic or history of recurrent infection: consider the risks/benefits. If a serious infection develops or is not responding to standard therapy, monitor closely and discontinue until resolves. Evaluate for TB infection prior to initiating; monitor for active TB during and after therapy. Patients with active TB infection: do not initiate. History of latent or active TB; consider anti-TB therapy prior to initiation. Discontinue if Crohn’s disease develops. Pregnancy. Nursing mothers.
REMS
Siliq Pharmacokinetics
See Literature
Siliq Interactions
Interactions
Avoid concomitant live vaccines. Concomitant CYP450 substrates with a narrow therapeutic index (eg, warfarin, cyclosporine); monitor and consider adjusting dose.
Siliq Adverse Reactions
Adverse Reactions
Arthralgia, headache, fatigue, diarrhea, oropharyngeal pain, nausea, myalgia, inj site reactions, influenza, neutropenia, tinea infections.
Siliq Clinical Trials
See Literature
Siliq Note
Notes
Available only through a restricted program under a REMS called the SILIQ REMS Program. For more information, visit www.SILIQREMS.com or call (855) 511-6135.
Siliq Patient Counseling
See Literature
