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Seysara Generic Name & Formulations
Legal Class
Rx
General Description
Sarecycline 60mg, 100mg, 150mg; tabs.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs—30
Manufacturer
Generic Availability
NO
Seysara Indications
Indications
Non-nodular moderate-to-severe acne vulgaris.
Limitations of Use
Efficacy beyond 12 weeks and safety beyond 12 months: not established. Not evaluated in treating infections.
Seysara Dosage and Administration
Adults and Children
<9yrs: not recommended. Take with fluids. ≥9yrs (33–54kg): 60mg once daily; (55–84kg): 100mg once daily; (85–136kg): 150mg once daily. Re-evaluate if no improvement after 12 weeks.
Seysara Contraindications
Not Applicable
Seysara Boxed Warnings
Not Applicable
Seysara Warnings/Precautions
Warnings/Precautions
Discontinue if superinfection develops. History of intracranial hypertension. Monitor for visual disturbances. Overweight women. Evaluate if diarrhea occurs; discontinue if C. difficile-associated diarrhea is suspected or confirmed. Avoid sun or UV light. Pregnancy (during 2nd & 3rd trimester): may cause permanent discoloration of the teeth or reversible inhibition of bone growth. Nursing mothers: not recommended.
Seysara Pharmacokinetics
See Literature
Seysara Interactions
Interactions
Avoid concomitant penicillins, oral retinoids. May need to reduce concomitant anticoagulant dose. Separate dosing from antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, and iron-containing products. Concomitant P-gp substrates (eg, digoxin); monitor for toxicity and reduce dose as needed.
Seysara Adverse Reactions
Adverse Reactions
Nausea; tooth discoloration, enamel hypoplasia, inhibition of bone growth (up to 8yrs of age), C.difficile-associated diarrhea, intracranial hypertension, photosensitivity, CNS effects, male infertility.
Seysara Clinical Trials
See Literature
Seysara Note
Not Applicable
Seysara Patient Counseling
See Literature
