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Minocycline Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline (as HCl) 50mg, 75mg, 100mg; caps.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Contact supplier
Manufacturer
Minocycline Indications
Indications
Adjunct in severe acne.
Minocycline Dosage and Administration
Adult
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily.
Children
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours.
Minocycline Contraindications
Not Applicable
Minocycline Boxed Warnings
Not Applicable
Minocycline Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. Pregnancy, nursing mothers: not recommended.
Minocycline Pharmacokinetics
See Literature
Minocycline Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test.
Minocycline Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Minocycline Clinical Trials
See Literature
Minocycline Note
Notes
Formerly known under the brand name Dynacin.
Minocycline Patient Counseling
See Literature
Minocycline Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline (as HCl) 50mg, 75mg, 100mg; caps.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Contact supplier
Manufacturer
Minocycline Indications
Indications
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.
Minocycline Dosage and Administration
Adult
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Syphilis: treat for 10–15 days. Meningococcal carrier state: 100mg every 12 hours for 5 days. Mycobacterium marinum infection: 100mg every 12 hours for 6–8 weeks has been used. Uncomplicated urethral, endocervical, or rectal infection w. C.trachomatis or U. urealyticum: 100mg every 12 hours for at least 7 days. For men: Uncomplicated gonococcal infection (not urethritis or anorectal): 200mg once then 100mg every 12 hours for at least 4 days; urethritis: 100mg every 12 hours for 5 days.
Children
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours.
Minocycline Contraindications
Not Applicable
Minocycline Boxed Warnings
Not Applicable
Minocycline Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. Pregnancy, nursing mothers: not recommended.
Minocycline Pharmacokinetics
See Literature
Minocycline Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test.
Minocycline Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Minocycline Clinical Trials
See Literature
Minocycline Note
Notes
Formerly known under the brand name Dynacin.
Minocycline Patient Counseling
See Literature
