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Minocin Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline (as HCl) 50mg, 100mg; pellet-filled caps.
Pharmacological Class
Tetracycline antibiotic.
See Also
How Supplied
Caps—60; Single-use vials—1, 10
Manufacturer
Minocin Indications
Indications
Adjunct in severe acne.
Minocin Dosage and Administration
Adult
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.
Minocin Contraindications
Not Applicable
Minocin Boxed Warnings
Not Applicable
Minocin Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
Minocin Pharmacokinetics
See Literature
Minocin Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Minocin Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
Minocin Clinical Trials
See Literature
Minocin Note
Not Applicable
Minocin Patient Counseling
See Literature
Minocin Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline (as HCl) 50mg, 100mg; pellet-filled caps.
Pharmacological Class
Tetracycline antibiotic.
See Also
How Supplied
Caps—60; Single-use vials—1, 10
Manufacturer
Minocin Indications
Indications
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.
Minocin Dosage and Administration
Adult
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Syphilis: treat for 10–15 days. Meningococcal carrier state: 100mg every 12 hours for 5 days. Mycobacterium marinum infection: 100mg every 12 hours for 6–8 weeks has been used. Uncomplicated urethral, endocervical, or rectal infection w. C.trachomatis or U. urealyticum: 100mg every 12 hours for at least 7 days. For men: Uncomplicated gonococcal infection (not urethritis or anorectal): 200mg once then 100mg every 12 hours for at least 4 days; urethritis: 100mg every 12 hours for 5 days. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.
Minocin Contraindications
Not Applicable
Minocin Boxed Warnings
Not Applicable
Minocin Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
Minocin Pharmacokinetics
See Literature
Minocin Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Minocin Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
Minocin Clinical Trials
See Literature
Minocin Note
Not Applicable
Minocin Patient Counseling
See Literature
Minocin Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline (as HCl) 50mg, 100mg; pellet-filled caps.
Pharmacological Class
Tetracycline antibiotic.
See Also
How Supplied
Caps—60; Single-use vials—1, 10
Manufacturer
Minocin Indications
Indications
Adjunct in acute intestinal amebiasis.
Minocin Dosage and Administration
Adult
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.
Minocin Contraindications
Not Applicable
Minocin Boxed Warnings
Not Applicable
Minocin Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
Minocin Pharmacokinetics
See Literature
Minocin Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Minocin Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
Minocin Clinical Trials
See Literature
Minocin Note
Not Applicable
Minocin Patient Counseling
See Literature
