Metvixia Generic Name & Formulations
Legal Class
Rx
General Description
Methyl aminolevulinate 16.8%; crm.
Pharmacological Class
Porphyrin precursor.
How Supplied
Crm—2g
Manufacturer
Metvixia Indications
Indications
For treatment of thin and moderately thick, non-hyperkeratotic, non-pigmented actinic keratoses of the face and scalp in immunocompetent patients, in combination with Aktilite CL128 lamp red light illumination.
Metvixia Dosage and Administration
Adult
See literature. Surface of lesion should be prepared before applying. Use nitrile gloves. Apply a layer of cream about 1mm thick to lesion and surrounding 5mm of normal skin. Do not apply more than 1g (half tube) per treatment session. Cover area with occlusive, non-absorbent dressing for 3 hours. Multiple lesions may be treated during the same session. Remove occlusive dressing and clean area with saline and gauze. Position Aktilite CL128 lamp. Required illumination time: 7–10 minutes. Keep area covered and away from light for at least 48 hours after. Two treatment sessions one week apart should be administered. Assess lesion response 3 months after the last treatment session.
Children
<18yrs: not recommended.
Metvixia Contraindications
Contraindications
Cutaneous photosensitivity. Porphyrin, peanut, or almond oil allergy.
Metvixia Boxed Warnings
Not Applicable
Metvixia Warnings/Precautions
Warnings/Precautions
Do not apply to eyes, mucous membranes. Avoid exposure to sunlight or bright indoor light during the period prior to Aktilite red light treatment. If red light treatment cannot be administered, remove cream and protect skin from sunlight or intense light for two days. Coagulation defects. Pregnancy (Cat.C). Nursing mothers.
Metvixia Pharmacokinetics
See Literature
Metvixia Interactions
Interactions
Additive photosensitivity possible with concomitant photosensitizing agents.
Metvixia Adverse Reactions
Adverse Reactions
Erythema, pain, burning and discomfort, pruritus, scabbing, crusting and erosions, edema and exfoliation of skin.
Metvixia Clinical Trials
See Literature
Metvixia Note
Not Applicable
Metvixia Patient Counseling
See Literature