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Loryna Generic Name & Formulations
Legal Class
Rx
General Description
Drospirenone 3mg, ethinyl estradiol 20micrograms (24 tabs); inert (4 tabs).
Pharmacological Class
Progestin + estrogen.
How Supplied
Packs—3
Manufacturer
Loryna Indications
Indications
Moderate acne vulgaris in females ≥14 years of age, who have no known contraindications to oral contraceptive therapy, have achieved menarche, and desire contraception.
Loryna Dosage and Administration
Adult
1 tab daily for 28 days; repeat.
Children
Not applicable.
Loryna Contraindications
Contraindications
Thrombophlebitis or thromboembolic disorders. Cerebral vascular or coronary artery disease. Renal, hepatic, or adrenal insufficiency. Severe hypertension. Valvular heart disease. Diabetes with vascular involvement. Headaches with focal neurological symptoms. Major surgery with prolonged immobilization. Heavy smoking (>15 cigarettes per day) and over age 35. Breast or other estrogen-dependent neoplasms. Undiagnosed abnormal genital bleeding. Cholestatic jaundice of pregnancy or jaundice with prior OC use. Hepatic adenoma or carcinoma. Pregnancy (Cat.X).
Loryna Boxed Warnings
Not Applicable
Loryna Warnings/Precautions
Warnings/Precautions
Hypertriglyceridemia. Discontinue if jaundice, visual disturbances, migraine or other severe headaches occur. Do regular complete physical exams. May need barrier contraception with Sunday starts or postpartum use (see literature). Monitor K+ during 1st cycle if risk of hyperkalemia. Nursing mothers: not recommended.
Loryna Pharmacokinetics
See Literature
Loryna Interactions
Interactions
Antagonized by hepatic enzyme inducing drugs (eg, rifampin, griseofulvin, St. John's wort), possibly others. May affect measurement of sex hormone-binding globulin levels. Monitor K+ during 1st cycle with drugs that increase potassium (eg, ACE inhibitors, angiotensin receptor blockers, NSAIDs, K+ sparing diuretics).
Loryna Adverse Reactions
Adverse Reactions
Hypertension, nausea, vomiting, breakthrough bleeding, amenorrhea, transient delay of ovulation after discontinuation, edema, chloasma, mastodynia, headache, intolerance to contact lenses. Increased risk of gallbladder disease, thromboembolic disorders.
Loryna Clinical Trials
See Literature
Loryna Note
Not Applicable
Loryna Patient Counseling
See Literature
Loryna Generic Name & Formulations
Legal Class
Rx
General Description
Drospirenone 3mg, ethinyl estradiol 20micrograms (24 tabs); inert (4 tabs).
Pharmacological Class
Progestin + estrogen.
How Supplied
Packs—3
Manufacturer
Loryna Indications
Indications
Oral contraception.
Loryna Dosage and Administration
Adult
1 tab daily for 28 days; repeat.
Children
Not applicable.
Loryna Contraindications
Contraindications
Thrombophlebitis or thromboembolic disorders. Cerebral vascular or coronary artery disease. Renal, hepatic, or adrenal insufficiency. Severe hypertension. Valvular heart disease. Diabetes with vascular involvement. Headaches with focal neurological symptoms. Major surgery with prolonged immobilization. Heavy smoking (>15 cigarettes per day) and over age 35. Breast or other estrogen-dependent neoplasms. Undiagnosed abnormal genital bleeding. Cholestatic jaundice of pregnancy or jaundice with prior OC use. Hepatic adenoma or carcinoma. Pregnancy (Cat.X).
Loryna Boxed Warnings
Not Applicable
Loryna Warnings/Precautions
Warnings/Precautions
Hypertriglyceridemia. Discontinue if jaundice, visual disturbances, migraine or other severe headaches occur. Do regular complete physical exams. May need barrier contraception with Sunday starts or postpartum use (see literature). Monitor K+ during 1st cycle if risk of hyperkalemia. Nursing mothers: not recommended.
Loryna Pharmacokinetics
See Literature
Loryna Interactions
Interactions
Antagonized by hepatic enzyme inducing drugs (eg, rifampin, griseofulvin, St. John's wort), possibly others. May affect measurement of sex hormone-binding globulin levels. Monitor K+ during 1st cycle with drugs that increase potassium (eg, ACE inhibitors, angiotensin receptor blockers, NSAIDs, K+ sparing diuretics).
Loryna Adverse Reactions
Adverse Reactions
Hypertension, nausea, vomiting, breakthrough bleeding, amenorrhea, transient delay of ovulation after discontinuation, edema, chloasma, mastodynia, headache, intolerance to contact lenses. Increased risk of gallbladder disease, thromboembolic disorders.
Loryna Clinical Trials
See Literature
Loryna Note
Not Applicable
Loryna Patient Counseling
See Literature
