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Fluticasone Propionate Cream Generic Name & Formulations
Legal Class
Rx
General Description
Fluticasone propionate 0.05%.
See Also
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Fluticasone Propionate Cream Indications
Indications
Corticosteroid-responsive dermatoses.
Fluticasone Propionate Cream Dosage and Administration
Adults and Children
<3mos: not established. ≥3mos: apply a thin film to affected areas twice daily; atopic dermatitis: 1–2 times daily. Discontinue when control is achieved (max 4 weeks in children). Do not occlude.
Fluticasone Propionate Cream Contraindications
Contraindications
Formaldehyde allergy.
Fluticasone Propionate Cream Boxed Warnings
Not Applicable
Fluticasone Propionate Cream Warnings/Precautions
Warnings/Precautions
Avoid use near eyes, on face, groin, or axillae. Do not use for diaper dermatitis, rosacea, perioral dermatitis, or on pre-existing skin atrophy. Avoid tight-fitting diapers or plastic pants. Risk of HPA axis suppression with high-potency steroids, prolonged use, application to large surface area, use of occlusive dressings, altered skin barrier, liver failure, young age; discontinue gradually, or reduce dose or potency if occurs. Treat infection if present; discontinue if infection persists or worsens. Lotion: avoid excessive sun exposure. Reevaluate periodically. Pregnancy. Nursing mothers: avoid direct infant exposure.
Fluticasone Propionate Cream Pharmacokinetics
Elimination
Fecal. Half-life: ~10 hours.
Fluticasone Propionate Cream Interactions
Not Applicable
Fluticasone Propionate Cream Adverse Reactions
Adverse Reactions
Burning, stinging, pruritus, irritation, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae, miliaria, erythema, dry skin, excoriation; HPA axis suppression (esp. in children); ophthalmic reactions (eg, cataracts, glaucoma).
Fluticasone Propionate Cream Clinical Trials
See Literature
Fluticasone Propionate Cream Note
Notes
Formerly known under the brand name Cutivate.
Fluticasone Propionate Cream Patient Counseling
See Literature
