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Efudex Cream Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 5%.
Pharmacological Class
Antimetabolite.
See Also
How Supplied
Soln (w. drop dispenser)—10mL, 25mL; Crm—40g
Manufacturer
Generic Availability
YES
Efudex Cream Indications
Indications
Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling.
Efudex Cream Dosage and Administration
Adult
Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).
Children
Not established.
Efudex Cream Contraindications
Contraindications
Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy.
Efudex Cream Boxed Warnings
Not Applicable
Efudex Cream Warnings/Precautions
Warnings/Precautions
Do not apply into eyes, nose, or mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Advise patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.
Efudex Cream Pharmacokinetics
See Literature
Efudex Cream Interactions
Not Applicable
Efudex Cream Adverse Reactions
Adverse Reactions
Burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, ulceration; leukocytosis.
Efudex Cream Clinical Trials
See Literature
Efudex Cream Note
Not Applicable
Efudex Cream Patient Counseling
See Literature
Efudex Cream Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 5%.
Pharmacological Class
Antimetabolite.
See Also
How Supplied
Soln (w. drop dispenser)—10mL, 25mL; Crm—40g
Manufacturer
Generic Availability
YES
Efudex Cream Indications
Indications
Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling.
Efudex Cream Dosage and Administration
Adult
Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).
Children
Not established.
Efudex Cream Contraindications
Contraindications
Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy.
Efudex Cream Boxed Warnings
Not Applicable
Efudex Cream Warnings/Precautions
Warnings/Precautions
Do not apply into eyes, nose, or mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Advise patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.
Efudex Cream Pharmacokinetics
See Literature
Efudex Cream Interactions
Not Applicable
Efudex Cream Adverse Reactions
Adverse Reactions
Burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, ulceration; leukocytosis.
Efudex Cream Clinical Trials
See Literature
Efudex Cream Note
Not Applicable
Efudex Cream Patient Counseling
See Literature
