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Efudex Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 2%; soln.
Pharmacological Class
Antimetabolite.
See Also
How Supplied
Soln (w. drop dispenser)—10mL, 25mL; Crm—40g
Manufacturer
Generic Availability
YES
Efudex Indications
Indications
Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling.
Efudex Dosage and Administration
Adult
Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).
Children
Not established.
Efudex Contraindications
Contraindications
Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy.
Efudex Boxed Warnings
Not Applicable
Efudex Warnings/Precautions
Warnings/Precautions
Do not apply into eyes, nose, or mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Advise patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.
Efudex Pharmacokinetics
See Literature
Efudex Interactions
Not Applicable
Efudex Adverse Reactions
Adverse Reactions
Burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, ulceration; leukocytosis.
Efudex Clinical Trials
See Literature
Efudex Note
Not Applicable
Efudex Patient Counseling
See Literature
Efudex Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 2%; soln.
Pharmacological Class
Antimetabolite.
See Also
How Supplied
Soln (w. drop dispenser)—10mL, 25mL; Crm—40g
Manufacturer
Generic Availability
YES
Efudex Indications
Indications
Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling.
Efudex Dosage and Administration
Adult
Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).
Children
Not established.
Efudex Contraindications
Contraindications
Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy.
Efudex Boxed Warnings
Not Applicable
Efudex Warnings/Precautions
Warnings/Precautions
Do not apply into eyes, nose, or mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Advise patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.
Efudex Pharmacokinetics
See Literature
Efudex Interactions
Not Applicable
Efudex Adverse Reactions
Adverse Reactions
Burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, ulceration; leukocytosis.
Efudex Clinical Trials
See Literature
Efudex Note
Not Applicable
Efudex Patient Counseling
See Literature
