Duobrii Generic Name & Formulations
Legal Class
Rx
General Description
Halobetasol propionate 0.01%, tazarotene 0.045%; lotion.
Pharmacological Class
Corticosteroid + retinoid.
How Supplied
Lotion—100g
Manufacturer
Generic Availability
NO
Duobrii Indications
Indications
Plaque psoriasis.
Duobrii Dosage and Administration
Adult
≥18yrs: apply a thin layer to affected areas once daily; max 50g/week. Discontinue when control is achieved. Do not occlude. Females of reproductive potential: initiate therapy during normal menses.
Children
<18yrs: not established.
Duobrii Contraindications
Contraindications
Pregnancy.
Duobrii Boxed Warnings
Not Applicable
Duobrii Warnings/Precautions
Warnings/Precautions
Not for oral, ophthalmic, or intravaginal use. Avoid use on the face, groin, or axillae. Risk of HPA axis suppression with high-potency corticosteroids, application to large surface areas, occlusive use, altered skin barrier, concomitant multiple corticosteroid-containing products, liver failure, young age; discontinue gradually or reduce dose, if occurs. Avoid use on eczematous or sunburned skin. Sun sensitivity. Increased risk of posterior subcapsular cataracts and glaucoma; monitor for visual symptoms. Treat infection if present or develops; discontinue until resolved. Reevaluate periodically. Embryo-fetal toxicity. Obtain reliable negative pregnancy test within 2wks before initiating therapy. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: avoid direct infant exposure.
Duobrii Pharmacokinetics
See Literature
Duobrii Interactions
Interactions
Caution with photosensitizers (eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides).
Duobrii Adverse Reactions
Adverse Reactions
Contact dermatitis, application site pain, folliculitis, skin atrophy, excoriation, rash, skin abrasion/exfoliation; local adverse reactions (eg, striae, telangiectasias), Cushing’s syndrome, hyperglycemia, glucosuria, HPA axis suppression (esp. in children).
Duobrii Clinical Trials
See Literature
Duobrii Note
Not Applicable
Duobrii Patient Counseling
See Literature