Doxycycline Hyclate Tablets

— THERAPEUTIC CATEGORIES —
  • Acne
  • Bacterial infections
  • Malaria
PAGE CONTENTS
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  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Doxycycline Hyclate Tablets Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Doxycycline (as hyclate) 100mg; tabs.

    Pharmacological Class

    Tetracycline antibiotic.

    See Also

    How Supplied

    Caps 100mg—50; Syrup—473mL; Susp—60mL; Tabs—Contact supplier.

    Manufacturer

    Various generic manufacturers

    Doxycycline Hyclate Tablets Indications

    Indications

    Adjunct in severe acne.

    Doxycycline Hyclate Tablets Dosage and Administration

    Adult

    Take with fluids. 100mg every 12hrs for 1 day, then 100mg/day in 1–2 divided doses. Reduce dose after improvement.

    Children

    Not applicable.

    Doxycycline Hyclate Tablets Contraindications

    Not Applicable

    Doxycycline Hyclate Tablets Boxed Warnings

    Not Applicable

    Doxycycline Hyclate Tablets Warnings/Precautions

    Warnings/Precautions

    Children ≤8yrs: weigh benefits vs. risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Discontinue if skin erythema, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Asthma (syrup). Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy. Nursing mothers: not recommended.

    Doxycycline Hyclate Tablets Pharmacokinetics

    See Literature

    Doxycycline Hyclate Tablets Interactions

    Interactions

    Antacids, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. May be antagonized by barbiturates, carbamazepine, phenytoin. Monitor prothrombin time with oral anticoagulants. May antagonize oral contraceptives. May interfere with fluorometric detection of urinary catecholamines.

    Doxycycline Hyclate Tablets Adverse Reactions

    Adverse Reactions

    Anorexia, nausea, vomiting, diarrhea, dysphagia, enterocolitis, pancreatitis, skin rashes (may be severe), photosensitivity, urticaria, blood dyscrasias; intracranial hypertension, C.difficile-associated diarrhea.

    Doxycycline Hyclate Tablets Clinical Trials

    See Literature

    Doxycycline Hyclate Tablets Note

    Notes

    Formerly known under the brand name Vibra-Tabs.

    Doxycycline Hyclate Tablets Patient Counseling

    See Literature

    Doxycycline Hyclate Tablets Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Doxycycline (as hyclate) 100mg; tabs.

    Pharmacological Class

    Tetracycline antibiotic.

    See Also

    How Supplied

    Caps 100mg—50; Syrup—473mL; Susp—60mL; Tabs—Contact supplier.

    Manufacturer

    Various generic manufacturers

    Doxycycline Hyclate Tablets Indications

    Indications

    Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma, specific bacterial (eg, relapsing fever). Alternative for selected infections when penicillin is contraindicated. Anthrax including inhalational anthrax (postexposure).

    Doxycycline Hyclate Tablets Dosage and Administration

    Adult

    Take with fluids. 100mg every 12hrs for 1 day; then 100mg daily; if severe: 100mg every 12hrs. Streptococcal infections: continue for 10 days. Uncomplicated urethral, endocervical, or rectal: 100mg twice daily for 7 days. Uncomplicated gonococcal: 100mg twice daily for 7 days or as an alternative single visit dose: 300mg stat, followed in one hr by a second 300mg dose. Nongonococcal urethritis: 100mg twice daily for 7 days. Early syphilis: (allergic to penicillin): 100mg twice daily for 2 weeks; syphilis >1 year's duration: treat for 4 weeks. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Postexposure inhalational anthrax: 100mg twice daily for 60 days (start as soon as possible after exposure).

    Children

    ≤8yrs: not usually recommended. >8yrs: Severe/life-threatening infections: (<45kg): 2.2mg/kg every 12hrs; (≥45kg): give adult dose. Less severe infections: (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg in 1–2 divided doses; (≥45kg): give adult dose. Postexposure inhalational anthrax: (<45kg): 2.2mg/kg twice daily for 60 days; (≥45kg): give adult dose.

    Doxycycline Hyclate Tablets Contraindications

    Not Applicable

    Doxycycline Hyclate Tablets Boxed Warnings

    Not Applicable

    Doxycycline Hyclate Tablets Warnings/Precautions

    Warnings/Precautions

    Children ≤8yrs: weigh benefits vs. risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Discontinue if skin erythema, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Asthma (syrup). Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy. Nursing mothers: not recommended.

    Doxycycline Hyclate Tablets Pharmacokinetics

    See Literature

    Doxycycline Hyclate Tablets Interactions

    Interactions

    Antacids, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. May be antagonized by barbiturates, carbamazepine, phenytoin. Monitor prothrombin time with oral anticoagulants. May antagonize oral contraceptives. May interfere with fluorometric detection of urinary catecholamines.

    Doxycycline Hyclate Tablets Adverse Reactions

    Adverse Reactions

    Anorexia, nausea, vomiting, diarrhea, dysphagia, enterocolitis, pancreatitis, skin rashes (may be severe), photosensitivity, urticaria, blood dyscrasias; intracranial hypertension, C.difficile-associated diarrhea.

    Doxycycline Hyclate Tablets Clinical Trials

    See Literature

    Doxycycline Hyclate Tablets Note

    Not Applicable

    Doxycycline Hyclate Tablets Patient Counseling

    See Literature

    Doxycycline Hyclate Tablets Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Doxycycline (as hyclate) 100mg; tabs.

    Pharmacological Class

    Tetracycline antibiotic.

    See Also

    How Supplied

    Caps 100mg—50; Syrup—473mL; Susp—60mL; Tabs—Contact supplier.

    Manufacturer

    Various generic manufacturers

    Doxycycline Hyclate Tablets Indications

    Indications

    Short term prophylaxis of malaria due to P. falciparum.

    Doxycycline Hyclate Tablets Dosage and Administration

    Adult

    Take with fluids. 100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.

    Children

    ≤8yrs: not recommended. >8yrs: 2mg/kg daily; max 100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.

    Doxycycline Hyclate Tablets Contraindications

    Not Applicable

    Doxycycline Hyclate Tablets Boxed Warnings

    Not Applicable

    Doxycycline Hyclate Tablets Warnings/Precautions

    Warnings/Precautions

    Children ≤8yrs: weigh benefits vs. risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Discontinue if skin erythema, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Asthma (syrup). Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy. Nursing mothers: not recommended.

    Doxycycline Hyclate Tablets Pharmacokinetics

    See Literature

    Doxycycline Hyclate Tablets Interactions

    Interactions

    Antacids, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. May be antagonized by barbiturates, carbamazepine, phenytoin. Monitor prothrombin time with oral anticoagulants. May antagonize oral contraceptives. May interfere with fluorometric detection of urinary catecholamines.

    Doxycycline Hyclate Tablets Adverse Reactions

    Adverse Reactions

    Anorexia, nausea, vomiting, diarrhea, dysphagia, enterocolitis, pancreatitis, skin rashes (may be severe), photosensitivity, urticaria, blood dyscrasias; intracranial hypertension, C.difficile-associated diarrhea.

    Doxycycline Hyclate Tablets Clinical Trials

    See Literature

    Doxycycline Hyclate Tablets Note

    Not Applicable

    Doxycycline Hyclate Tablets Patient Counseling

    See Literature

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