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Doryx Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 50mg, 80mg, 200mg; del-rel tabs.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs 50mg—120; 80mg—30; 200mg—60
Manufacturer
Generic Availability
YES
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Doryx Indications
Indications
Adjunct in severe acne.
Doryx Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs). Switching from Doryx to Doryx MPC: see full labeling.
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (>45kg): use Adult dose. Switching from Doryx to Doryx MPC: see full labeling.
Doryx Contraindications
Not Applicable
Doryx Boxed Warnings
Not Applicable
Doryx Warnings/Precautions
Warnings/Precautions
Not substitutable on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Perform ophthalmic exam if visual disturbances occur. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy. Nursing mothers.
Doryx Pharmacokinetics
Elimination
Fecal, renal. Half-life: 18–22 hours.
Doryx Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Doryx Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.
Doryx Clinical Trials
See Literature
Doryx Note
Not Applicable
Doryx Patient Counseling
See Literature
Doryx Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 50mg, 80mg, 200mg; del-rel tabs.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs 50mg—120; 80mg—30; 200mg—60
Manufacturer
Generic Availability
YES
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Doryx Indications
Indications
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma, specific bacterial (eg, relapsing fever). Alternative for selected infections when penicillin is contraindicated. Anthrax including inhalational anthrax (postexposure).
Doryx Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs); if severe infections (eg, chronic UTI): 100mg every 12 hours. Streptococcal infections: treat for 10 days. Uncomplicated urethral, endocervical, or rectal infection: 100mg twice daily for 7 days. Uncomplicated gonococcal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg once, followed by a second 300mg dose 1hr later. Nongonococcal urethritis (NGU): 100mg twice daily for 7 days. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Syphilis (allergic to penicillin): Early: 100mg twice daily for 2 weeks; >1yr duration: treat for 4 weeks. Anthrax: 100mg twice daily for 60 days. Switching from Doryx to Doryx MPC: see full labeling.
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: up to 4.4mg/kg daily; (>45kg): use Adult dose. Anthrax (<45kg): 2.2mg/kg twice daily for 60 days; (≥45kg): use Adult dose. Switching from Doryx to Doryx MPC: see full labeling.
Doryx Contraindications
Not Applicable
Doryx Boxed Warnings
Not Applicable
Doryx Warnings/Precautions
Warnings/Precautions
Not substitutable on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Perform ophthalmic exam if visual disturbances occur. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy. Nursing mothers.
Doryx Pharmacokinetics
Elimination
Fecal, renal. Half-life: 18–22 hours.
Doryx Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Doryx Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.
Doryx Clinical Trials
See Literature
Doryx Note
Notes
See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.
Doryx Patient Counseling
See Literature
Doryx Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 50mg, 80mg, 200mg; del-rel tabs.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs 50mg—120; 80mg—30; 200mg—60
Manufacturer
Generic Availability
YES
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Doryx Indications
Indications
Prophylaxis of malaria.
Doryx Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the area. 100mg daily. Switching from Doryx to Doryx MPC: see full labeling.
Children
≤8yrs: not recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the area. >8yrs: 2mg/kg once daily up to the adult dose. Switching from Doryx to Doryx MPC: see full labeling.
Doryx Contraindications
Not Applicable
Doryx Boxed Warnings
Not Applicable
Doryx Warnings/Precautions
Warnings/Precautions
Not substitutable on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Perform ophthalmic exam if visual disturbances occur. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy. Nursing mothers.
Doryx Pharmacokinetics
Elimination
Fecal, renal. Half-life: 18–22 hours.
Doryx Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Doryx Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.
Doryx Clinical Trials
See Literature
Doryx Note
Not Applicable
Doryx Patient Counseling
See Literature
Doryx Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 50mg, 80mg, 200mg; del-rel tabs.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs 50mg—120; 80mg—30; 200mg—60
Manufacturer
Generic Availability
YES
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Doryx Indications
Indications
Adjunct in acute intestinal amebiasis.
Doryx Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs). Switching from Doryx to Doryx MPC: see full labeling.
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (>45kg): use Adult dose. Switching from Doryx to Doryx MPC: see full labeling.
Doryx Contraindications
Not Applicable
Doryx Boxed Warnings
Not Applicable
Doryx Warnings/Precautions
Warnings/Precautions
Not substitutable on a mg-per-mg basis with other oral doxycyclines. Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Perform ophthalmic exam if visual disturbances occur. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy. Nursing mothers.
Doryx Pharmacokinetics
Elimination
Fecal, renal. Half-life: 18–22 hours.
Doryx Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Doryx Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.
Doryx Clinical Trials
See Literature
Doryx Note
Not Applicable
Doryx Patient Counseling
See Literature
