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Ventavis Generic Name & Formulations
Legal Class
Rx
General Description
Iloprost 10mcg/mL, 20mcg/mL; soln for inhalation using I-neb or Prodose AAD System; preservative-free.
Pharmacological Class
Prostacyclin analogue.
How Supplied
Single-use ampules—30
Manufacturer
Ventavis Indications
Indications
Pulmonary arterial hypertension (WHO Group I) in patients with NYHA Class III or IV symptoms to improve exercise ability and delay clinical worsening.
Ventavis Dosage and Administration
Adult
Initially 2.5mcg, if tolerated, uptitrate to 5micrograms 6–9 times daily based on tolerability (no more than every 2 hrs); max 45mcg/day. Monitor vital signs while initiating therapy. Hepatic impairment: consider increasing dosing interval (eg, 3–4 hours) between doses.
Children
Not recommended.
Ventavis Contraindications
Not Applicable
Ventavis Boxed Warnings
Not Applicable
Ventavis Warnings/Precautions
Warnings/Precautions
Do not start therapy if systolic BP <85 mmHg. Discontinue immediately if pulmonary edema occurs (may indicate pulmonary venous hypertension). Bleeding disorders. Avoid contact with skin, eyes, or oral ingestion. COPD. Severe asthma. Acute pulmonary infections. Hepatic or renal impairment. Elderly. Pregnancy. Nursing mothers: not recommended.
Ventavis Pharmacokinetics
See Literature
Ventavis Interactions
Interactions
Potentiates hypotensive effect of vasodilators and antihypertensives. May potentiate anticoagulants. Do not mix with other drugs.
Ventavis Adverse Reactions
Adverse Reactions
Vasodilation, increased cough, headache, lockjaw, insomnia, GI upset, hypotension, flu syndrome, back pain, abnormal lab tests (eg, increased GGT, alkaline phosphatase), tongue pain, palpitations, syncope, muscle cramps, hemoptysis, pneumonia, CHF, chest pain, supraventricular tachycardia, dyspnea, peripheral edema, kidney failure.
Ventavis Clinical Trials
See Literature
Ventavis Note
Not Applicable
Ventavis Patient Counseling
See Literature
