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Veltassa Generic Name & Formulations
Legal Class
Rx
General Description
Patiromer 8.4g, 16.8g, 25.2g; per pkt; pwd for oral susp.
Pharmacological Class
Potassium binder.
How Supplied
Single-use packets (8.4g)—4, 30; (16.8g, 25.2g)—30
Manufacturer
Generic Availability
NO
Mechanism of Action
Veltassa is a non-absorbed, cation exchange polymer that contains a calcium-sorbitol counterion. Veltassa increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels.
Veltassa Indications
Indications
Hyperkalemia.
Limitations of Use
Not for emergency treatment for life-threatening hyperkalemia due to its delayed onset of action.
Veltassa Dosage and Administration
Adult
Give at least 3hrs before or 3hrs after other oral medications (see Interactions). Take without regard to food; mix with water. Initially 8.4g once daily. Adjust dose in 8.4g increments as needed at ≥1-week intervals to obtain desired serum potassium target range; max 25.2g/day.
Children
Not established.
Veltassa Contraindications
Not Applicable
Veltassa Boxed Warnings
Boxed Warning
Binding to other oral medications.
Veltassa Warnings/Precautions
Warnings/Precautions
Avoid in severe constipation, bowel obstruction or impaction, abnormal post-op bowel motility disorders. Monitor serum potassium, magnesium. Consider magnesium supplementation if low serum levels develop.
Veltassa Pharmacokinetics
Elimination
Fecal.
Veltassa Interactions
Interactions
May reduce absorption and efficacy of other oral medications (eg, telmisartan, bisoprolol, carvedilol, nebivolol, ciprofloxacin, levothyroxine, metformin, mycophenolate mofetil, quinidine, thiamine); separate dosing by at least 3hrs.
Veltassa Adverse Reactions
Adverse Reactions
Constipation, hypomagnesemia, diarrhea, nausea, abdominal discomfort, flatulence.
Veltassa Clinical Trials
See Literature
Veltassa Note
Not Applicable
Veltassa Patient Counseling
See Literature
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