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Veletri Generic Name & Formulations
Legal Class
Rx
General Description
Epoprostenol (as sodium) 0.5mg, 1.5mg; per vial; pwd for IV infusion after reconstitution.
Pharmacological Class
Prostacyclin analogue.
How Supplied
Vial (10mL)—1
Manufacturer
Generic Availability
YES
Veletri Indications
Indications
Pulmonary arterial hypertension (PAH; WHO Group I) in patients with NYHA Class III or IV symptoms, to improve exercise ability.
Veletri Dosage and Administration
Adult
Give by continuous chronic IV infusion through a central venous catheter. Initially 2ng/kg/min; increase in increments of 1–2ng/kg/min at ≥15min intervals based on response. Decrease dose gradually in 2ng/kg/min decrements at ≥15min intervals until dose-limiting effects resolve.
Children
Not established.
Veletri Contraindications
Contraindications
Heart failure due to severe left ventricular systolic dysfunction. Pulmonary edema.
Veletri Boxed Warnings
Not Applicable
Veletri Warnings/Precautions
Warnings/Precautions
Avoid abrupt withdrawal or large dose reductions (may cause rebound pulmonary hypertension). Risk of pulmonary embolism or systemic embolism; give anticoagulant therapy unless contraindicated. Monitor BP and heart rate during initiation and after dose changes. Pregnancy. Nursing mothers.
Veletri Pharmacokinetics
See Literature
Veletri Interactions
Interactions
Hypotensive effects may be potentiated by diuretics, antihypertensive agents, other vasodilators. Increased risk of bleeding with anticoagulants, antiplatelets. May potentiate digoxin concentration; monitor for digoxin toxicity.
Veletri Adverse Reactions
Adverse Reactions
Nausea, vomiting, headache, hypotension, flushing, chest pain, dizziness, bradycardia, dyspnea, abdominal pain, musculoskeletal pain, tachycardia, jaw pain, diarrhea, flu-like symptoms, anxiety/nervousness.
Veletri Clinical Trials
See Literature
Veletri Note
Not Applicable
Veletri Patient Counseling
See Literature
