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Vasostrict Generic Name & Formulations
Legal Class
Rx
General Description
Vasopressin 20U/mL; soln for IV inj after dilution; 0.2U/mL, 0.4U/mL, 0.6U/mL; per premixed vial; soln for IV inj.
Pharmacological Class
Vasopressin (synthetic).
How Supplied
Single-dose vials (1mL)—10, 25; Multi-dose vial (10mL)—1; Premixed single-dose vials (100mL)—10
Manufacturer
Generic Availability
NO
Mechanism of Action
Vasopressin causes vasoconstriction by binding to V1 receptors on vascular smooth muscle coupled to the Gq/11-phospholipase C-phosphatidyl-inositol-triphosphate pathway, resulting in the release of intracellular calcium. In addition, vasopressin stimulates antidiuresis via stimulation of V2 receptors which are coupled to adenyl cyclase.
Vasostrict Indications
Indications
To increase blood pressure in adults with vasodilatory shock who remain hypotensive despite fluids and catecholamines.
Vasostrict Dosage and Administration
Adult
Use lowest effective dose. Post-cardiotomy shock: initially 0.03U/min; max 0.1U/min. Septic shock: initially 0.01U/min; max 0.07U/min. May titrate up by 0.005U/min at 10–15min intervals until target BP is achieved. After target BP maintained for 8hrs without use of catecholamines, taper by 0.005U/min every hour as tolerated to maintain target BP.
Children
Not established.
Vasostrict Contraindications
Contraindications
Multi-dose vial: chlorobutanol allergy.
Vasostrict Boxed Warnings
Not Applicable
Vasostrict Warnings/Precautions
Warnings/Precautions
Decrease in cardiac index may be observed. Reversible diabetes insipidus. Monitor serum electrolytes, fluid status, and urine output after discontinuation. Elderly. Pregnancy (2nd & 3rd trimester: may need to increase dose). Nursing mothers.
Vasostrict Pharmacokinetics
Elimination
Renal (minor). Half-life: ≤10 minutes.
Vasostrict Interactions
Interactions
Additive effect with concomitant catecholamines; monitor and adjust vasopressin dose as needed. May be potentiated by indomethacin, ganglionic blocking agents, SSRIs, tricyclics, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate; monitor and adjust vasopressin dose as needed. May be antagonized by demeclocycline, lithium, foscarnet, clozapine; monitor and adjust vasopressin dose as needed.
Vasostrict Adverse Reactions
Adverse Reactions
Decreased cardiac output, bradycardia, tachyarrhythmias, hyponatremia, ischemia (coronary, mesenteric, skin, digital).
Vasostrict Clinical Trials
See Literature
Vasostrict Note
Not Applicable
Vasostrict Patient Counseling
See Literature
