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Triamterene/hydrochlorothiazide Generic Name & Formulations
Legal Class
Rx
General Description
Triamterene 37.5mg, hydrochlorothiazide 25mg; caps.
Pharmacological Class
Diuretic (K+ sparing) + (thiazide).
How Supplied
Contact supplier
Manufacturer
Triamterene/hydrochlorothiazide Indications
Indications
Edema.
Triamterene/hydrochlorothiazide Dosage and Administration
Adult
1–2 caps once daily.
Children
Not established.
Triamterene/hydrochlorothiazide Contraindications
Contraindications
Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.
Triamterene/hydrochlorothiazide Boxed Warnings
Boxed Warning
Hyperkalemia.
Triamterene/hydrochlorothiazide Warnings/Precautions
Warnings/Precautions
Risk of hyperkalemia; monitor frequently. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Diabetes. Acidosis predisposition. Electrolyte imbalance. Hypochloremia with metabolic alkalosis. Excess diuresis. History of renal stones. Gout. Surgery. SLE. Monitor electrolytes, renal function. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Severely ill. Elderly. Pregnancy. Nursing mothers: not recommended.
Triamterene/hydrochlorothiazide Pharmacokinetics
See Literature
Triamterene/hydrochlorothiazide Interactions
Interactions
Digoxin, lithium toxicity. Hyperkalemia more likely with ACE inhibitors, parenteral penicillin G. Hypokalemia with ACTH, corticosteroids, amphotericin B. Hyponatremia with sulfonylureas. NSAIDs may cause renal failure. Adjust antidiabetic, antigout medications. May potentiate nondepolarizing muscle relaxants, antihypertensives. Antagonizes oral anticoagulants, methenamine. May interfere with parathyroid tests.
Triamterene/hydrochlorothiazide Adverse Reactions
Adverse Reactions
Drowsiness, muscle cramps, weakness, headache, GI disturbances, dizziness, impotence, arrhythmias, hypotension, dry mouth, urine discoloration; HCTZ: increased risk for non-melanoma skin cancer.
Triamterene/hydrochlorothiazide Clinical Trials
See Literature
Triamterene/hydrochlorothiazide Note
Notes
Formerly known under the brand name Dyazide.
Triamterene/hydrochlorothiazide Patient Counseling
See Literature
Triamterene/hydrochlorothiazide Generic Name & Formulations
Legal Class
Rx
General Description
Triamterene 37.5mg, hydrochlorothiazide 25mg; caps.
Pharmacological Class
Diuretic (K+ sparing) + (thiazide).
How Supplied
Contact supplier
Manufacturer
Triamterene/hydrochlorothiazide Indications
Indications
Hypertension when normokalemia is essential.
Triamterene/hydrochlorothiazide Dosage and Administration
Adult
1–2 caps once daily.
Children
Not established.
Triamterene/hydrochlorothiazide Contraindications
Contraindications
Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.
Triamterene/hydrochlorothiazide Boxed Warnings
Boxed Warning
Hyperkalemia.
Triamterene/hydrochlorothiazide Warnings/Precautions
Warnings/Precautions
Risk of hyperkalemia; monitor frequently. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Diabetes. Acidosis predisposition. Electrolyte imbalance. Hypochloremia with metabolic alkalosis. Excess diuresis. History of renal stones. Gout. Surgery. SLE. Monitor electrolytes, renal function. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Severely ill. Elderly. Pregnancy. Nursing mothers: not recommended.
Triamterene/hydrochlorothiazide Pharmacokinetics
See Literature
Triamterene/hydrochlorothiazide Interactions
Interactions
Digoxin, lithium toxicity. Hyperkalemia more likely with ACE inhibitors, parenteral penicillin G. Hypokalemia with ACTH, corticosteroids, amphotericin B. Hyponatremia with sulfonylureas. NSAIDs may cause renal failure. Adjust antidiabetic, antigout medications. May potentiate nondepolarizing muscle relaxants, antihypertensives. Antagonizes oral anticoagulants, methenamine. May interfere with parathyroid tests.
Triamterene/hydrochlorothiazide Adverse Reactions
Adverse Reactions
Drowsiness, muscle cramps, weakness, headache, GI disturbances, dizziness, impotence, arrhythmias, hypotension, dry mouth, urine discoloration; HCTZ: increased risk for non-melanoma skin cancer.
Triamterene/hydrochlorothiazide Clinical Trials
See Literature
Triamterene/hydrochlorothiazide Note
Notes
Formerly known under the brand name Dyazide.
Triamterene/hydrochlorothiazide Patient Counseling
See Literature
