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Torsemide Generic Name & Formulations
Legal Class
Rx
General Description
Torsemide 5mg, 10mg, 20mg, 100mg; scored tabs.
Pharmacological Class
Diuretic (loop).
How Supplied
Contact supplier.
Manufacturer
Torsemide Indications
Indications
Edema.
Torsemide Dosage and Administration
Adult
Edema due to CHF: 10–20mg once daily, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to renal disease: 20mg once daily, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to hepatic disease: 5–10mg once daily, give with aldosterone antagonist or potassium-sparing diuretic, may titrate upwards by doubling dose until desired response is achieved; max 40mg daily.
Children
Not established.
Torsemide Contraindications
Contraindications
Anuria. Hepatic coma. Sulfonamide or povidone allergy.
Torsemide Boxed Warnings
Not Applicable
Torsemide Warnings/Precautions
Warnings/Precautions
Hepatic disease with cirrhosis and ascites. New or worsening hepatic encephalopathy; consider suspending or discontinuing therapy. Renal impairment. Monitor electrolytes, blood glucose, renal function, and fluids. Pregnancy. Nursing mothers.
Torsemide Pharmacokinetics
See Literature
Torsemide Interactions
Interactions
Lithium or salicylate toxicity. Caution with NSAIDs. Antagonized by organic anion drugs (eg, probenecid) or indomethacin. Give oral dose 1hr before or 4–6hrs after cholestyramine. Ototoxicity with aminoglycosides (avoid) or ethacrynic acid. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. May affect sensitive CYP2C9 substrates or substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Risk of hypotension and/or renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs). Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids or ACTH.
Torsemide Adverse Reactions
Adverse Reactions
Excessive urination; hypotension, renal dysfunction, electrolyte abnormalities, hyperglycemia, hyperuricemia, ototoxicity.
Torsemide Clinical Trials
See Literature
Torsemide Note
Notes
Formerly known under the brand name Demadex.
Torsemide Patient Counseling
See Literature
Torsemide Generic Name & Formulations
Legal Class
Rx
General Description
Torsemide 5mg, 10mg, 20mg, 100mg; scored tabs.
Pharmacological Class
Diuretic (loop).
How Supplied
Contact supplier.
Manufacturer
Torsemide Indications
Indications
Hypertension.
Torsemide Dosage and Administration
Adult
Initially 5mg once daily; may increase to 10mg daily after 4–6 weeks.
Children
Not established.
Torsemide Contraindications
Contraindications
Anuria. Hepatic coma. Sulfonamide or povidone allergy.
Torsemide Boxed Warnings
Not Applicable
Torsemide Warnings/Precautions
Warnings/Precautions
Hepatic disease with cirrhosis and ascites. New or worsening hepatic encephalopathy; consider suspending or discontinuing therapy. Renal impairment. Monitor electrolytes, blood glucose, renal function, and fluids. Pregnancy. Nursing mothers.
Torsemide Pharmacokinetics
See Literature
Torsemide Interactions
Interactions
Lithium or salicylate toxicity. Caution with NSAIDs. Antagonized by organic anion drugs (eg, probenecid) or indomethacin. Give oral dose 1hr before or 4–6hrs after cholestyramine. Ototoxicity with aminoglycosides (avoid) or ethacrynic acid. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. May affect sensitive CYP2C9 substrates or substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Risk of hypotension and/or renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs). Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids or ACTH.
Torsemide Adverse Reactions
Adverse Reactions
Excessive urination; hypotension, renal dysfunction, electrolyte abnormalities, hyperglycemia, hyperuricemia, ototoxicity.
Torsemide Clinical Trials
See Literature
Torsemide Note
Notes
Formerly known under the brand name Demadex.
Torsemide Patient Counseling
See Literature
