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Ticlopidine Hcl Generic Name & Formulations
Legal Class
Rx
General Description
Ticlopidine HCl 250mg; tabs.
Pharmacological Class
Platelet aggregation inhibitor.
How Supplied
Contact supplier.
Manufacturer
Ticlopidine Hcl Indications
Indications
To reduce the risk of thrombotic stroke in selected patients intolerant of aspirin.
Ticlopidine Hcl Dosage and Administration
Adult
250mg twice daily with food.
Children
Not recommended.
Ticlopidine Hcl Contraindications
Contraindications
Hematopoietic disorders including neutropenia, thrombocytopenia, or history of thrombotic thrombocytopenic purpura (TTP). Hemostatic or active bleeding disorders. Severe hepatic impairment.
Ticlopidine Hcl Boxed Warnings
Not Applicable
Ticlopidine Hcl Warnings/Precautions
Warnings/Precautions
Monitor for hematologic toxicity at baseline, every 2 weeks for the first 3 months, and for 2 weeks after discontinuation; test more frequently if signs of hematological changes occur. Discontinue if neutropenia or TTP occur. Renal or hepatic impairment. Bleeding risk (eg, ulcers). Discontinue 10–14 days before surgery. Hyperlipidemia. Pregnancy (Cat.B). Nursing mothers: not recommended.
Ticlopidine Hcl Pharmacokinetics
See Literature
Ticlopidine Hcl Interactions
Interactions
Discontinue anticoagulants, fibrinolytics before use. Avoid aspirin. Potentiates aspirin, NSAIDs, anticoagulants, antipyrine, theophylline. Antacids reduce absorption. May be potentiated by cimetidine. Monitor phenytoin. May antagonize digoxin. Caution with propranolol, drugs that increase risk of bleeding, and drugs metabolized by CYP450.
Ticlopidine Hcl Adverse Reactions
Adverse Reactions
Diarrhea, GI upset, rash, neutropenia, pruritus, dizziness, anorexia, abnormal liver function tests, bleeding complications, hyperlipidemia, TTP, aplastic anemia, agranulocytosis, other blood dyscrasis, jaundice.
Ticlopidine Hcl Clinical Trials
See Literature
Ticlopidine Hcl Note
Notes
Formerly known under the brand name Ticlid.
Ticlopidine Hcl Patient Counseling
See Literature
